Hemophagocytic lymph histiocytosis (HLH): etiologies, pathogenesis, treatment, and outcomes in critically ill patients: a review article and literature to review.
Hemophagocytic
diagnosis
etiologies
lymph histiocytosis
pathogenesis
review
treatment
Journal
Journal of community hospital internal medicine perspectives
ISSN: 2000-9666
Titre abrégé: J Community Hosp Intern Med Perspect
Pays: United States
ID NLM: 101601396
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
Hemophagocytic lymph histiocytosis (HLH) is not an independent disease but is instead a clinical syndrome that occurs in many underlying conditions involving all age groups. HLH is the consequence of a severe, uncontrolled hyperinflammatory reaction that in most cases is triggered by an infectious agent. Acquired HLH is much more common than primary HLH syndrome but primary is more fatal, and it does have the worst prognosis with no definitive treatment available to date. This review article mentioned all the latest advancements regarding etiologies, pathogenesis, treatment, and outcomes in critically ill patients who got diagnosed with HLH syndrome in last 15 years.
Identifiants
pubmed: 34567455
doi: 10.1080/20009666.2021.1954783
pii: 1954783
pmc: PMC8462863
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
639-645Informations de copyright
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center.
Déclaration de conflit d'intérêts
No potential conflict of interest was reported by the author(s).
Références
J Intensive Care Med. 2020 Dec;35(12):1476-1482
pubmed: 30862243
Blood. 2015 Mar 5;125(10):1548-52
pubmed: 25573993
Crit Care. 2020 May 24;24(1):244
pubmed: 32448380
Pediatr Blood Cancer. 2007 Feb;48(2):124-31
pubmed: 16937360
Pediatr Crit Care Med. 2015 Jul;16(6):e165-73
pubmed: 25901543
Pediatr Crit Care Med. 2019 Apr;20(4):e185-e190
pubmed: 30520798
Blood. 2019 Jun 6;133(23):2465-2477
pubmed: 30992265
Pediatr Crit Care Med. 2013 May;14(4):e176-81
pubmed: 23439459
Pediatr Crit Care Med. 2019 Jul;20(7):e311-e318
pubmed: 31149968
Crit Care Med. 2020 Nov;48(11):e1137-e1146
pubmed: 32947471
Medicine (Baltimore). 2015 Dec;94(51):e2318
pubmed: 26705219
World J Crit Care Med. 2018 Nov 30;7(6):73-83
pubmed: 30596029
Crit Care Med. 2020 Apr;48(4):599-600
pubmed: 32205609
Shock. 2020 Jun;53(6):701-709
pubmed: 31626037
Crit Care Med. 2020 Apr;48(4):459-465
pubmed: 32205591
Lancet Rheumatol. 2020 Jun;2(6):e358-e367
pubmed: 32373790
J Intensive Care Med. 2020 Feb;35(2):118-127
pubmed: 30384814
J Intensive Care Med. 2019 Sep;34(9):723-731
pubmed: 28631531