A 3D-printed modular magnetic digital microfluidic architecture for on-demand bioanalysis.
Biosensors
Microfluidics
Journal
Microsystems & nanoengineering
ISSN: 2055-7434
Titre abrégé: Microsyst Nanoeng
Pays: England
ID NLM: 101695458
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
11
2019
revised:
22
01
2020
accepted:
29
02
2020
entrez:
27
9
2021
pubmed:
29
6
2020
medline:
29
6
2020
Statut:
epublish
Résumé
Magnetic digital microfluidics (MDM) manipulates fluids in the form of droplets on an open substrate, and incorporates surface energy traps (SETs) to facilitate the droplet manipulation. Conventional MDM devices are fabricated monolithically, which makes it difficult to modify the device configuration without completely overhauling the original design. In this paper, we present a modular MDM architecture that enables rapid on-demand configuration and re-configuration of MDM platforms for customized bioanalyses. Each modular component contains a SET and a Lego-like antistud that fits onto a base board with Lego-like studs. We illustrate the versatility of the modular MDM architecture in biomarker sensing, pathogen identification, antibiotic resistance determination, and biochemical quantification by demonstrating immunoassays, phenotypical assays and enzymatic assays on various modular MDM platforms configured on demand to accomplish the fluidic operations required by assorted bioanalytical assays. The modular MDM architecture promises great potential for point-of-care diagnostics by offering on-demand customization of testing platforms for various categories of diagnostic assays. It also provides a new avenue for microfluidic assay development with its high configurability which would significantly reduce the time and cost of the development cycle.
Identifiants
pubmed: 34567660
doi: 10.1038/s41378-020-0152-4
pii: 152
pmc: PMC8433373
doi:
Types de publication
Journal Article
Langues
eng
Pagination
48Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare that they have no conflict of interest.
Références
Lab Chip. 2009 Nov 21;9(22):3303-5
pubmed: 19865740
Sci Rep. 2018 Jun 28;8(1):9793
pubmed: 29955160
Anal Chem. 2002 Jun 15;74(12):2637-52
pubmed: 12090654
Drugs. 2007;67(7):1027-52
pubmed: 17488146
J Clin Microbiol. 2013 Sep;51(9):3097-101
pubmed: 23824767
Lab Chip. 2013 Dec 21;13(24):4827-31
pubmed: 24162777
Lab Chip. 2016 Sep 21;16(19):3700-3707
pubmed: 27722698
Angew Chem Int Ed Engl. 2008;47(21):3900-4
pubmed: 18412211
Appl Environ Microbiol. 1985 Dec;50(6):1383-7
pubmed: 3911904
Lab Chip. 2011 Feb 7;11(3):398-406
pubmed: 21046055
Anal Chem. 2002 Jun 15;74(12):2623-36
pubmed: 12090653
Int J Bioprint. 2017 Jun 06;3(2):001
pubmed: 33094185
Adv Mater. 2013 Jun 4;25(21):2903-8
pubmed: 23529938
Microfluid Nanofluidics. 2012 Mar 1;12(5):787-794
pubmed: 22707926
Microsyst Nanoeng. 2018 Nov 19;4:34
pubmed: 31057922
Biophys J. 2006 Feb 15;90(4):1396-410
pubmed: 16299079
J Biophotonics. 2008 Sep;1(4):287-98
pubmed: 19343652
Lab Chip. 2008 Aug;8(8):1374-8
pubmed: 18651081
Lab Chip. 2018 Mar 13;18(6):890-901
pubmed: 29372201
Anal Chem. 2013 Jan 15;85(2):451-72
pubmed: 23140554
Nat Med. 2007 Oct;13(10):1259-63
pubmed: 17891145
Biosens Bioelectron. 2013 Dec 15;50:91-9
pubmed: 23835223
Microfluid Nanofluidics. 2014 Aug;17(2):425-430
pubmed: 25386112
Electrophoresis. 2019 Feb 16;:
pubmed: 30770588
Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9745-50
pubmed: 15985549
Biomed Microdevices. 2010 Dec;12(6):1043-9
pubmed: 20632111
Lab Chip. 2019 Jun 25;19(13):2178-2191
pubmed: 31179467
Microsyst Nanoeng. 2016 Feb 29;2:15049
pubmed: 31057813
Antimicrob Agents Chemother. 2014 Dec;58(12):7553-6
pubmed: 25246404
Beilstein J Nanotechnol. 2017 Jun 9;8:1238-1249
pubmed: 28685124
Microsyst Nanoeng. 2019 Oct 21;5:56
pubmed: 31645999
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15013-8
pubmed: 25246553
Lab Chip. 2017 Mar 14;17(6):994-1008
pubmed: 28220916