Overexpression of Galectin-1 and Galectin-3 in hepatocellular carcinoma.
Cirrhosis
Epithelial-mesenchymal transition (EMT)
Fibrosis
Galectin-1 (Gal-1)
Galectin-3 (Gal-3)
Hepatocellular carcinoma (HCC)
Liver cancer
Metastasis
Non-alcoholic steatohepatitis (NASH)
Journal
Liver research
ISSN: 2096-2878
Titre abrégé: Liver Res
Pays: China
ID NLM: 101705555
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
ppublish
Résumé
Galectins (Gals) are evolutionarily conserved proteins that bind to β-galactoside containing glycans. Abnormal expression of Gals is associated with the development, progression, and metastasis of different types of cancer. Among the 11 Gals identified in humans, the roles of Gal-1 and Gal-3 have been extensively investigated in various tumors. Here, we summarize the roles of overly expressed Gal-1 and Gal-3 in the pathogenesis of hepatocellular carcinoma (HCC). The overexpression of Gal-1 and Gal-3 correlates with tumor growth, HCC cell migration and invasion, tumor aggressiveness, metastasis, and poor prognosis. A potentially promising future treatment strategy for HCC may include the combination of immunotherapy with Gal-1 inhibition. Additional research is warranted to investigate targeting Gal-1 and Gal-3 for HCC treatment.
Identifiants
pubmed: 34567824
doi: 10.1016/j.livres.2020.11.001
pmc: PMC8460053
mid: NIHMS1655976
doi:
Types de publication
Journal Article
Langues
eng
Pagination
173-179Subventions
Organisme : NCI NIH HHS
ID : R01 CA222490
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA108459
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA179582
Pays : United States
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no conflict of interest.
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