Association Between Coronary Artery Disease and Plasma Omentin-1 Levels.
cad
cardiovascular disease
coronary artery disease
intelectin-1
omentin-1
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
accepted:
21
08
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
Omentin-1 is secreted from visceral adipose tissue that contributes to chronic inflammatory diseases' pathogenesis, including cardiovascular events. In this case-control study, we will determine the association between plasma omentin and coronary artery disease (CAD). This is a case-control study, conducted from June 2020 to April 2021 in the cardiology unit of a tertiary care hospital in Pakistan. Patients diagnosed with CAD (n = 300) within the last six months were included in the study. Another 300 participants without CAD and with similar demographic profiles were included in the control group. A blood sample of 5 ml was drawn from participants of both groups and sent to the laboratory to test for plasma omentin level. Plasma omentin level was significantly lower in patients with CAD compared to the patients without CAD (61.21 ± 10.21 ng/dL vs. 95.22 ± 12.21 ug/L; p-value: <0.0001). In both genders, the plasma omentin-1 was lower in patients with CAD compared to patients without CAD (p-value: <0.0001). The present study revealed a negative association between omentin-1 and CAD. We speculate that low levels of omentin-1 might play a role in the pathogenesis of atherosclerosis. Therefore, plasma omentin-1 can be a potential biomarker to predict the development and progression of CAD.
Identifiants
pubmed: 34567888
doi: 10.7759/cureus.17347
pmc: PMC8454460
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e17347Informations de copyright
Copyright © 2021, Bai et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Curr Cardiol Rev. 2020;16(3):198-201
pubmed: 32392116
Biomarkers. 2011 Dec;16(8):657-62
pubmed: 21988056
N Engl J Med. 2010 Apr 29;362(17):1575-85
pubmed: 20228401
Diabetes. 2007 Jun;56(6):1655-61
pubmed: 17329619
Clin Exp Pharmacol Physiol. 2011 Dec;38(12):888-96
pubmed: 21910745
Cardiovasc Res. 2016 May 1;110(1):1-3
pubmed: 26935810
Cardiovasc Res. 2016 May 1;110(1):118-28
pubmed: 26790473
Future Cardiol. 2018 Nov;14(6):491-509
pubmed: 30409037
Biochim Biophys Acta. 2005 Dec 30;1732(1-3):96-102
pubmed: 16386808
J Atheroscler Thromb. 2017 Sep 1;24(9):940-948
pubmed: 28123148
Lancet. 2004 Sep 11-17;364(9438):937-52
pubmed: 15364185
Diabetes Res Clin Pract. 2011 Jul;93(1):21-5
pubmed: 21497934
Dis Markers. 2017;2017:8208609
pubmed: 29238120
Data Brief. 2015 Dec 11;6:158-61
pubmed: 26862554
Curr Med Chem. 2014;21(34):3936-48
pubmed: 25174928
J Biol Chem. 2012 Jan 2;287(1):408-417
pubmed: 22081609
Lancet. 2015 Jan 10;385(9963):117-71
pubmed: 25530442