Valproic Acid: A Promising Therapeutic Agent in Glioma Treatment.
anti-tumor effects
clinical trials
glioma
synergistic effects
valproic acid (VPA)
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
03
2021
accepted:
20
08
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
Glioma, characterized by infiltrative growth and treatment resistance, is regarded as the most prevalent intracranial malignant tumor. Due to its poor prognosis, accumulating investigation has been performed for improvement of overall survival (OS) and progression-free survival (PFS) in glioma patients. Valproic acid (VPA), one of the most common histone deacetylase inhibitors (HDACIs), has been detected to directly or synergistically exert inhibitory effects on glioma
Identifiants
pubmed: 34568018
doi: 10.3389/fonc.2021.687362
pmc: PMC8461314
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
687362Informations de copyright
Copyright © 2021 Han and Guan.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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