Breast Lesions Diagnosed as Ductal Carcinoma
core needle biopsy
ductal carcinoma in situ
platelet
risk predictor
underestimation
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
05
2021
accepted:
23
08
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
The major concern over preoperatively diagnosed ductal carcinoma Medical records of 260 patients preoperatively diagnosed with DCIS The concomitant invasive carcinoma was overlooked in 75 out of 260 patients (29.3%). Multivariate analysis revealed that presence of microinvasion, presence of abnormal lymph node on ultrasound, and absent linear or segmental distributed calcification on mammography were independent risk predictors for invasive carcinoma. Fourteen patients had lymph node metastasis, and five of them were in the non-invasive group. The presence of abnormal lymph node on ultrasound and increased ratio of platelet distribution width to platelet crit (PDW/PCT) (>52.85) were identified as independent risk predictors for ALN metastasis. For patients diagnosed with DCIS preoperatively, appropriate ALN management is necessary if they have risk predictors for concomitant invasive carcinoma and ALN metastasis.
Sections du résumé
BACKGROUND
BACKGROUND
The major concern over preoperatively diagnosed ductal carcinoma
METHODS
METHODS
Medical records of 260 patients preoperatively diagnosed with DCIS
RESULTS
RESULTS
The concomitant invasive carcinoma was overlooked in 75 out of 260 patients (29.3%). Multivariate analysis revealed that presence of microinvasion, presence of abnormal lymph node on ultrasound, and absent linear or segmental distributed calcification on mammography were independent risk predictors for invasive carcinoma. Fourteen patients had lymph node metastasis, and five of them were in the non-invasive group. The presence of abnormal lymph node on ultrasound and increased ratio of platelet distribution width to platelet crit (PDW/PCT) (>52.85) were identified as independent risk predictors for ALN metastasis.
CONCLUSION
CONCLUSIONS
For patients diagnosed with DCIS preoperatively, appropriate ALN management is necessary if they have risk predictors for concomitant invasive carcinoma and ALN metastasis.
Identifiants
pubmed: 34568047
doi: 10.3389/fonc.2021.717198
pmc: PMC8461168
doi:
Types de publication
Journal Article
Langues
eng
Pagination
717198Informations de copyright
Copyright © 2021 Liu, Wang, Zheng, Yu, Jin and Jin.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Surg Oncol. 2006 Jun 1;93(7):559-63
pubmed: 16705731
J Clin Oncol. 2013 Nov 1;31(31):3997-4013
pubmed: 24101045
Breast. 2012 Oct;21(5):641-5
pubmed: 22749854
Clin Breast Cancer. 2018 Oct;18(5):e805-e812
pubmed: 29798815
Eur J Cancer. 2007 Apr;43(6):993-1001
pubmed: 17300928
J Exp Med. 2005 Apr 4;201(7):1089-99
pubmed: 15809353
Breast Cancer. 2010 Oct;17(4):276-80
pubmed: 19756924
Breast. 2013 Oct;22(5):869-73
pubmed: 23601760
J Surg Oncol. 2015 Oct;112(5):476-80
pubmed: 26346047
Br J Cancer. 1998 Mar;77(6):956-64
pubmed: 9528841
Blood. 2012 Aug 30;120(9):1899-907
pubmed: 22797697
Ann Surg Oncol. 2011 May;18(5):1342-8
pubmed: 21042943
Am Surg. 2001 Sep;67(9):907-12
pubmed: 11565774
Can Assoc Radiol J. 2012 May;63(2):146-52
pubmed: 21561735
Breast J. 2011 May-Jun;17(3):223-9
pubmed: 21545433
J Clin Pathol. 2009 Jun;62(6):534-8
pubmed: 19190009
PLoS One. 2017 Dec 7;12(12):e0189166
pubmed: 29216259
Cancer Res. 2005 Aug 15;65(16):7241-8
pubmed: 16103075
Anticancer Res. 2020 Jul;40(7):3947-3952
pubmed: 32620636
Pathol Oncol Res. 2015 Jul;21(3):535-46
pubmed: 25573591
Breast. 2013 Aug;22(4):537-42
pubmed: 23237921
J Surg Oncol. 2013 Mar;107(4):388-92
pubmed: 23007901
Radiology. 2013 Oct;269(1):54-60
pubmed: 23771915
Microsc Res Tech. 2002 Oct 15;59(2):92-101
pubmed: 12373719
Radiology. 2009 Jan;250(1):41-9
pubmed: 18955508
Breast Cancer Res Treat. 2012 Apr;132(3):895-915
pubmed: 22048814
Asian Pac J Cancer Prev. 2014;15(1):55-60
pubmed: 24528005
Eur J Radiol. 2014 Jun;83(6):935-941
pubmed: 24666513
Arch Pathol Lab Med. 2010 Jul;134(7):e48-72
pubmed: 20586616
Ultrasonography. 2014 Apr;33(2):128-35
pubmed: 24936506
Radiology. 2001 Feb;218(2):497-502
pubmed: 11161168
Eur J Surg Oncol. 2008 Jun;34(6):631-5
pubmed: 17851019
Ann Surg. 1998 Jun;227(6):932-9
pubmed: 9637557
Cancer Sci. 2014 May;105(5):576-82
pubmed: 24533797
Clin Oncol (R Coll Radiol). 2013 May;25(5):275-82
pubmed: 23453783
Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):7-13
pubmed: 20950955
Cancer. 2008 May 15;112(10):2130-42
pubmed: 18383519
Eur J Surg Oncol. 2005 Dec;31(10):1105-11
pubmed: 16084681
Cancer. 2003 Nov 15;98(10):2105-13
pubmed: 14601079
Ann Surg Oncol. 2013 Aug;20(8):2576-81
pubmed: 23468047
JAMA Oncol. 2016 Aug 1;2(8):1083-8
pubmed: 27253401
Blood. 2018 Apr 19;131(16):1777-1789
pubmed: 29519806
Breast Cancer Res Treat. 2015 Oct;153(3):477-91
pubmed: 26341751
J Clin Oncol. 2002 Sep 1;20(17):3628-36
pubmed: 12202663
Radiology. 2011 Jul;260(1):119-28
pubmed: 21493791
Blood. 2007 Feb 1;109(3):1010-7
pubmed: 17032920
J Ultrasound Med. 1996 Mar;15(3):241-6
pubmed: 8919506