Case Report: Contrasting BCL2 Upregulation With Venetoclax in a Case of Refractory Lymphomatoid Papulosis and Progressive Chronic Lymphocytic Leukemia.
T-cell lymphoma
chronic lymphocytic leukemia
lymphomatoid papulosis (LyP)
lymphomatoid papulosis treatment
venetoclax (BCL2 inhibitor)
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
06
2021
accepted:
30
07
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
A 57-year-old man affected by high-risk progressive chronic lymphocytic leukemia (CLL), primary resistant to first-line chemoimmunotherapy, developed a type A lymphomatoid papulosis (LyP) during a second progression of CLL. The two blood tumor entities were clonally unrelated. LyP presented with a diffuse (>90% body surface area) cutaneous rash and was characterized by intensely pruriginous dusky nodules (n = 10) and red flat-topped papules (n = 60). No response to topical corticosteroids and psoralen plus ultraviolet A (PUVA) phototherapy was observed. In order to effectively treat progressive
Identifiants
pubmed: 34568060
doi: 10.3389/fonc.2021.729106
pmc: PMC8459905
doi:
Types de publication
Case Reports
Langues
eng
Pagination
729106Informations de copyright
Copyright © 2021 Guarente, Martino, Dorillo, De Falco, Rompietti, Sorcini, Brogna, Cardinali, Ascani, Marra and Sportoletti.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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