Bridging Tumorigenesis and Therapy Resistance With a Non-Darwinian and Non-Lamarckian Mechanism of Adaptive Evolution.
adaptation
cancer therapy
cell growth
environment
natural selection
stress response
tumor evolution
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
06
2021
accepted:
25
08
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
Although neo-Darwinian (and less often Lamarckian) dynamics are regularly invoked to interpret cancer's multifarious molecular profiles, they shine little light on how tumorigenesis unfolds and often fail to fully capture the frequency and breadth of resistance mechanisms. This uncertainty frames one of the most problematic gaps between science and practice in modern times. Here, we offer a theory of adaptive cancer evolution, which builds on a molecular mechanism that lies outside neo-Darwinian and Lamarckian schemes. This mechanism coherently integrates non-genetic and genetic changes, ecological and evolutionary time scales, and shifts the spotlight away from positive selection towards purifying selection, genetic drift, and the creative-disruptive power of environmental change. The surprisingly simple
Identifiants
pubmed: 34568068
doi: 10.3389/fonc.2021.732081
pmc: PMC8462274
doi:
Types de publication
Journal Article
Langues
eng
Pagination
732081Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 Catania, Ujvari, Roche, Capp and Thomas.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Mol Ecol. 2018 Aug;27(15):3040-3054
pubmed: 29920826
Trends Pharmacol Sci. 2012 Apr;33(4):207-14
pubmed: 22398146
Acta Pharmacol Sin. 2017 Mar;38(3):382-391
pubmed: 28042875
Biochim Biophys Acta Rev Cancer. 2017 Apr;1867(2):139-150
pubmed: 28161395
Nature. 2020 Feb;578(7796):615-620
pubmed: 31959985
Genes Dev. 2018 May 1;32(9-10):620-638
pubmed: 29802124
Nature. 2020 Feb;578(7793):122-128
pubmed: 32025013
Trends Ecol Evol. 2008 Jan;23(1):38-44
pubmed: 18006185
Oncogenesis. 2016 Jan 25;5:e190
pubmed: 26807645
PLoS Genet. 2013 Nov;9(11):e1003972
pubmed: 24278038
Nat Rev Immunol. 2008 Jan;8(1):59-73
pubmed: 18097448
Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9674-9
pubmed: 26195783
Science. 2005 Nov 18;310(5751):1193-6
pubmed: 16293764
J Biol Chem. 2001 May 25;276(21):17779-87
pubmed: 11279136
Nat Genet. 2015 Mar;47(3):209-16
pubmed: 25665006
Prog Biophys Mol Biol. 2012 Sep;110(1):69-86
pubmed: 22579660
J Cell Biochem. 2018 Jan;119(1):213-222
pubmed: 28513879
BMC Biol. 2010 May 21;8:66
pubmed: 20492640
Cancer Metastasis Rev. 2009 Jun;28(1-2):15-33
pubmed: 19169796
Cancer Res. 2009 Jun 1;69(11):4894-903
pubmed: 19487300
PLoS Comput Biol. 2020 Oct 26;16(10):e1007727
pubmed: 33104710
Cell. 2020 Dec 23;183(7):1848-1866.e26
pubmed: 33301708
Heredity (Edinb). 2012 Apr;108(4):347-53
pubmed: 22045380
EMBO J. 2010 Apr 7;29(7):1272-84
pubmed: 20186124
Elife. 2021 Mar 30;10:
pubmed: 33784238
Genetics. 1963 Oct;48:1303-12
pubmed: 14071753
Genome Res. 2015 Feb;25(2):189-200
pubmed: 25373142
Cell. 1997 Feb 7;88(3):323-31
pubmed: 9039259
Exp Gerontol. 2003 Jul;38(7):807-11
pubmed: 12855292
Genes Cancer. 2011 Apr;2(4):466-74
pubmed: 21779514
Nat Rev Cancer. 2006 Dec;6(12):924-35
pubmed: 17109012
Elife. 2019 Oct 01;8:
pubmed: 31573512
J Cell Biol. 2011 Jan 24;192(2):209-18
pubmed: 21263025
Ann Oncol. 2001 Jan;12(1):23-7
pubmed: 11249045
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Mol Oncol. 2011 Aug;5(4):315-23
pubmed: 21852209
Semin Reprod Endocrinol. 1999;17(3):275-90
pubmed: 10797946
Elife. 2021 Jan 25;10:
pubmed: 33491650
Cell. 2016 Sep 8;166(6):1585-1596.e22
pubmed: 27594428
Nat Med. 2016 Jul;22(7):792-9
pubmed: 27322744
Nature. 2010 Jul 8;466(7303):234-7
pubmed: 20574421
PLoS Biol. 2018 Dec 18;16(12):e3000069
pubmed: 30562346
Nature. 2020 Mar;579(7800):507-517
pubmed: 32214253
Dev Cell. 2017 Nov 6;43(3):257-258
pubmed: 29112847
Bioessays. 2016 Jul;38 Suppl 1:S65-74
pubmed: 27417124
Cold Spring Harb Perspect Med. 2016 Aug 01;6(8):
pubmed: 27329033
Nat Genet. 2017 Oct;49(10):1502-1510
pubmed: 28846101
Integr Comp Biol. 2020 Aug 1;60(2):332-347
pubmed: 32483607
Nat Rev Cancer. 2004 Feb;4(2):143-53
pubmed: 14732866
Br J Haematol. 2016 Nov;175(3):476-489
pubmed: 27470916
Nature. 2012 Jun 28;486(7404):537-40
pubmed: 22722843
Nat Rev Clin Oncol. 2017 Oct;14(10):611-629
pubmed: 28397828
Nat Commun. 2018 Mar 8;9(1):1005
pubmed: 29520061
PLoS Biol. 2017 May 9;15(5):e2000644
pubmed: 28486496
Science. 1999 Jul 9;285(5425):251-4
pubmed: 10398601
Int J Mol Sci. 2017 May 04;18(5):
pubmed: 28471386
J Biol Chem. 2009 Aug 21;284(34):22825-33
pubmed: 19546228
Cell. 2012 Dec 7;151(6):1308-18
pubmed: 23217712
FEBS Lett. 2004 Jan 16;557(1-3):136-42
pubmed: 14741356
Bioessays. 2021 Feb;43(2):e2000126
pubmed: 33184914
Proc Biol Sci. 2012 Dec 22;279(1749):5048-57
pubmed: 22977152
Trends Genet. 2012 Mar;28(3):128-36
pubmed: 22265392
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3171-8
pubmed: 23918358
Cancers (Basel). 2021 May 03;13(9):
pubmed: 34063648
Nat Rev Genet. 2016 Jul;17(7):379-91
pubmed: 27087500
Ann N Y Acad Sci. 2009 Jun;1168:23-51
pubmed: 19566702
Mol Cell Biol. 2019 Apr 16;39(9):
pubmed: 30745413
Nat Genet. 2006 Apr;38(4):484-8
pubmed: 16550173
PLoS Genet. 2011 Jun;7(6):e1001389
pubmed: 21695228
Science. 1961 Nov 10;134(3489):1501-6
pubmed: 14471768
Phys Biol. 2011 Feb;8(1):015001
pubmed: 21301065
Br J Cancer. 2018 Jan;118(2):145-152
pubmed: 29337961
Nature. 2011 Mar 10;471(7337):216-9
pubmed: 21390129
Nat Med. 2004 Aug;10(8):789-99
pubmed: 15286780
Open Biol. 2018 Jun;8(6):
pubmed: 29950452
Nat Commun. 2014 Oct 27;5:5281
pubmed: 25345443
Evolution. 2007 Nov;61(11):2469-79
pubmed: 17714500
Nat Rev Genet. 2019 Jul;20(7):404-416
pubmed: 30918367
Adv Genet. 1961;10:257-93
pubmed: 14004267
PLoS Comput Biol. 2021 Feb 11;17(2):e1008701
pubmed: 33571199
Cancer Res. 2004 Nov 15;64(22):8357-64
pubmed: 15548705
Nature. 1968 Feb 17;217(5129):624-6
pubmed: 5637732
Curr Genet. 2019 Dec;65(6):1287-1295
pubmed: 31076843
Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22745-50
pubmed: 21149740
Br J Cancer. 1954 Mar;8(1):1-12
pubmed: 13172380
Plant Physiol. 2008 Oct;148(2):993-1003
pubmed: 18715958
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):961-8
pubmed: 20080596
Genome Biol Evol. 2020 May 1;12(5):626-638
pubmed: 32163147
Prog Biophys Mol Biol. 2018 May;134:27-37
pubmed: 29223657
Mol Cell. 2018 Nov 1;72(3):583-593.e4
pubmed: 30293780
J Theor Biol. 1996 Feb 21;178(4):375-80
pubmed: 8733476
J Clin Invest. 2010 Jun;120(6):2030-9
pubmed: 20501944
Evolution (N Y). 2011 Dec;4(4):624-634
pubmed: 23705033
Nat Rev Genet. 2017 Jul;18(7):411-424
pubmed: 28502977
Nature. 2020 Jan;577(7789):260-265
pubmed: 31853061
Oncogene. 2002 Apr 4;21(15):2295-308
pubmed: 11948413
Nat Rev Genet. 2021 Apr;22(4):251-262
pubmed: 33257848
Genome Biol. 2018 Jul 24;19(1):95
pubmed: 30041675
Elife. 2018 Apr 05;7:
pubmed: 29620524
Cold Spring Harb Perspect Med. 2016 Jun 01;6(6):
pubmed: 27252396
NPJ Precis Oncol. 2019 Mar 6;3:7
pubmed: 30854468
Biomark Res. 2020 Sep 29;8:49
pubmed: 33005420
Nature. 2019 Jul;571(7766):489-499
pubmed: 31341302
Mol Biol Evol. 2020 Oct 1;37(10):2989-3002
pubmed: 32658971
Bioessays. 2021 Feb;43(2):e2000301
pubmed: 33283294
J Cell Biol. 2015 May 25;209(4):485-91
pubmed: 26008741
Plant Commun. 2020 Aug 13;1(6):100103
pubmed: 33367264
Proc Natl Acad Sci U S A. 1971 Apr;68(4):820-3
pubmed: 5279523
Nat Commun. 2019 Jun 20;10(1):2723
pubmed: 31222014
Evolution. 2013 Dec;67(12):3512-22
pubmed: 24299404
Nat Rev Genet. 2009 May;10(5):336-42
pubmed: 19337290
Mol Biol Evol. 2016 Oct;33(10):2515-29
pubmed: 27352853
Nature. 2015 Feb 12;518(7538):240-4
pubmed: 25409150
Nat Rev Clin Oncol. 2018 Mar;15(3):139-150
pubmed: 29297505
Blood. 2015 Nov 26;126(22):2491-501
pubmed: 26438511
Mol Biol Cell. 2016 Apr 15;27(8):1383-96
pubmed: 26941329
Cold Spring Harb Perspect Biol. 2010 Jun;2(6):a001198
pubmed: 20516129
Nat Ecol Evol. 2017 May 22;1(6):158
pubmed: 28812631
Proc Biol Sci. 2003 Jul 22;270(1523):1433-40
pubmed: 12965006
Bioessays. 2012 Jan;34(1):72-82
pubmed: 22105565
Philos Trans R Soc Lond B Biol Sci. 2019 Aug 19;374(1779):20180227
pubmed: 31431178
Nature. 2021 Apr;592(7852):80-85
pubmed: 33692543
Front Oncol. 2018 Sep 10;8:355
pubmed: 30250824
Cancer Res. 2019 Aug 1;79(15):3806-3814
pubmed: 31300477
Biophys Rev. 2018 Apr;10(2):667-676
pubmed: 29468522
Cell. 2017 Jun 15;169(7):1177-1186
pubmed: 28622505
Nat Commun. 2015 Mar 09;6:6367
pubmed: 25751731
Genome Biol Evol. 2015 Apr 26;7(5):1296-302
pubmed: 25917417
Nat Rev Clin Oncol. 2020 Nov;17(11):675-686
pubmed: 32699310
Nat Rev Cancer. 2013 Oct;13(10):714-26
pubmed: 24060863
Trends Ecol Evol. 2014 Jan;29(1):33-41
pubmed: 24148292
PLoS Genet. 2014 Feb 27;10(2):e1004185
pubmed: 24586206
Science. 2017 Jul 21;357(6348):
pubmed: 28729483
Science. 1976 Oct 1;194(4260):23-8
pubmed: 959840
PLoS One. 2019 Feb 1;14(2):e0202065
pubmed: 30707705
Hum Mutat. 2016 Sep;37(9):865-76
pubmed: 27328919
Front Oncol. 2019 Aug 21;9:794
pubmed: 31497535
Front Genet. 2013 Dec 10;4:285
pubmed: 24368911
Cell. 2015 Sep 10;162(6):1271-85
pubmed: 26359985
Nat Med. 2011 Mar;17(3):320-9
pubmed: 21383745
Cancers (Basel). 2021 Mar 18;13(6):
pubmed: 33803675
Int J Epidemiol. 2006 Oct;35(5):1163-5
pubmed: 16990287
Trends Cancer. 2018 Feb;4(2):110-118
pubmed: 29458961
Evolution. 2011 Jul;65(7):1827-40
pubmed: 21729041
Nat Commun. 2020 Feb 5;11(1):729
pubmed: 32024854
Mutat Res. 2005 Jan 6;569(1-2):75-85
pubmed: 15603753
Mol Biol Cell. 2013 Jul;24(14):2186-200
pubmed: 23699397
Mol Cancer Ther. 2007 May;6(5):1544-51
pubmed: 17513603
Nat Commun. 2013;4:2467
pubmed: 24045430
Trends Genet. 2020 Mar;36(3):203-214
pubmed: 31952840
Science. 2005 Mar 25;307(5717):1928-33
pubmed: 15790847
Br J Cancer. 2020 Feb;122(4):465-472
pubmed: 31831859
Cancer Cell. 2017 Aug 14;32(2):169-184.e7
pubmed: 28810143
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2910-5
pubmed: 23388632
Genes Dev. 2016 Jan 1;30(1):64-77
pubmed: 26701264
Mol Biol Evol. 2015 Apr;32(4):1097-108
pubmed: 25576365
Proc Biol Sci. 2017 May 31;284(1855):
pubmed: 28566483
Nat Rev Mol Cell Biol. 2019 Nov;20(11):665-680
pubmed: 31253954
EMBO Rep. 2012 Nov 6;13(11):968-70
pubmed: 23044824
PLoS Biol. 2017 Jun 27;15(6):e2001333
pubmed: 28654659
Nature. 2021 Feb;590(7847):642-648
pubmed: 33536616
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3585-9
pubmed: 1059147
Development. 2018 Apr 13;145(8):
pubmed: 29654218
Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7386-7391
pubmed: 29941601
Oncogenesis. 2021 Jan 5;10(1):8
pubmed: 33431808
J Cell Sci. 2020 Mar 6;133(5):
pubmed: 32144194
Sci Adv. 2021 Feb 3;7(6):
pubmed: 33536214
Nat Rev Drug Discov. 2020 Jan;19(1):39-56
pubmed: 31601994
Genome Res. 2011 Jul;21(7):1131-8
pubmed: 21422276
Front Oncol. 2018 Mar 06;8:50
pubmed: 29560343
Nature. 2013 Oct 17;502(7471):333-339
pubmed: 24132290
Adv Genet. 2008;61:247-67
pubmed: 18282509
Cell. 2019 May 16;177(5):1330-1345.e18
pubmed: 30982598
Trends Cell Biol. 2019 Aug;29(8):623-634
pubmed: 31153655
Dev Cell. 2009 Dec;17(6):755-73
pubmed: 20059947
Nat Rev Genet. 2005 Feb;6(2):119-27
pubmed: 15716908
Nat Commun. 2021 Jan 28;12(1):646
pubmed: 33510149
Genome Biol. 2019 Dec 24;20(1):298
pubmed: 31874648
Cold Spring Harb Perspect Med. 2017 Feb 1;7(2):
pubmed: 28148564
PLoS Genet. 2008 Dec;4(12):e1000304
pubmed: 19081788
Open Biol. 2020 Apr;10(4):190297
pubmed: 32289242
Science. 2019 Jun 07;364(6444):
pubmed: 31171663
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18545-50
pubmed: 20876136
Trends Cancer. 2021 Apr;7(4):309-322
pubmed: 33536158
Nat Commun. 2018 Mar 23;9(1):1215
pubmed: 29572503
PLoS Genet. 2016 Jan 11;12(1):e1005774
pubmed: 26752180
Nat Rev Cancer. 2014 Nov;14(11):747-53
pubmed: 25253389
Genome Med. 2011 Nov 29;3(11):75
pubmed: 22126538
Curr Opin Cell Biol. 2018 Jun;52:136-144
pubmed: 29625384
Cancer Res. 2019 Jul 15;79(14):3737-3748
pubmed: 31085700
Curr Biol. 2020 May 18;30(10):R465-R471
pubmed: 32428483
Nat Commun. 2012;3:1072
pubmed: 22990868
Cell. 2010 Mar 19;140(6):883-99
pubmed: 20303878
Nat Rev Genet. 2013 Nov;14(11):751-64
pubmed: 24105273
Biochem J. 2002 Aug 1;365(Pt 3):825-32
pubmed: 11936954
Bioessays. 2016 Nov;38(11):1111-1116
pubmed: 27644006
Heredity (Edinb). 2007 Oct;99(4):364-73
pubmed: 17622265
Nat Rev Cancer. 2016 Nov;16(11):694-707
pubmed: 27634449
Nat Rev Genet. 2008 Aug;9(8):583-93
pubmed: 18591982
Oncogene. 2013 Jun 20;32(25):3101-10
pubmed: 22824801
Biochim Biophys Acta Rev Cancer. 2017 Apr;1867(2):162-166
pubmed: 28341421
Nature. 2017 Jun 15;546(7658):431-435
pubmed: 28607484
Elife. 2019 Feb 26;8:
pubmed: 30803482
Semin Cell Dev Biol. 2009 Sep;20(7):869-76
pubmed: 19595782
N Engl J Med. 2016 Sep 1;375(9):819-29
pubmed: 27433843
Nat Rev Genet. 2016 Oct 14;17(11):704-714
pubmed: 27739533
Nature. 2019 Mar;567(7749):479-485
pubmed: 30894752
Bioessays. 2021 Jun;43(6):e2100049
pubmed: 33829521
Proc Natl Acad Sci U S A. 2021 May 18;118(20):
pubmed: 33972434
Gynecol Oncol. 2015 Apr;137(1):173-9
pubmed: 25677064
PLoS Genet. 2013;9(9):e1003714
pubmed: 24068943
PLoS Genet. 2009 Jun;5(6):e1000495
pubmed: 19503600
Nat Commun. 2019 Jun 24;10(1):2766
pubmed: 31235692
Nature. 2012 Jan 11;481(7382):506-10
pubmed: 22237025
Cell. 2017 Nov 16;171(5):1029-1041.e21
pubmed: 29056346
Int J Cancer. 2015 Feb 15;136(4):E188-96
pubmed: 25156304
Nature. 2012 Jan 18;481(7381):306-13
pubmed: 22258609
Cancer Cell. 2020 Aug 10;38(2):229-246.e13
pubmed: 32707077
Front Chem. 2016 Feb 11;4:6
pubmed: 26904537