"Ways in which the neonatal Fc-receptor is involved in autoimmunity".
Autoimmune disease
Autoimmunity
FcRn, Neonatal Fc receptor
IC, Immune complexes
Monoclonal therapeutic antibodies
Neonatal Fc receptor
mAbs, Monoclonal antibodies
Journal
Journal of translational autoimmunity
ISSN: 2589-9090
Titre abrégé: J Transl Autoimmun
Pays: Netherlands
ID NLM: 101759413
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
07
2021
accepted:
06
09
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
Since the neonatal IgG Fc receptor (FcRn) was discovered, its role has evolved from immunoglobulin recycling and biodistribution to antigen presentation and immune complex routing, bringing it to the center of both humoral and cellular immune responses. FcRn is thus involved in the pathophysiology of immune-related diseases such as cancer, infection, and autoimmune disorders. This review focuses on the role of FcRn in autoimmunity, based on the available data from both animal models and human studies. The knowledge concerning ways in which FcRn is involved in autoimmune response has led to the development of inhibitors for the treatment of autoimmune diseases, also described here. Up to date, the literature remains scarce, shedding light on the need for further studies to fully understand the various pathophysiological roles of this unique receptor.
Identifiants
pubmed: 34568803
doi: 10.1016/j.jtauto.2021.100122
pii: S2589-9090(21)00042-3
pmc: PMC8449123
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100122Informations de copyright
© 2021 Published by Elsevier B.V.
Références
J Allergy Clin Immunol. 2020 Sep;146(3):479-491.e5
pubmed: 32896308
J Mol Med (Berl). 2008 Aug;86(8):951-9
pubmed: 18542899
Clin Immunol. 2010 Sep;136(3):419-25
pubmed: 20627700
J Immunol. 2002 May 15;168(10):5326-32
pubmed: 11994491
J Allergy Clin Immunol. 2020 Sep;146(3):467-478
pubmed: 32896307
Ther Adv Neurol Disord. 2021 Jan 27;14:1756286420986747
pubmed: 33552238
Front Endocrinol (Lausanne). 2021 Jan 05;11:606434
pubmed: 33469446
Immunol Rev. 1998 Aug;164:209-29
pubmed: 9795778
Am J Med. 1977 Nov;63(5):729-34
pubmed: 337799
Ann Clin Transl Neurol. 2016 May 17;3(7):547-51
pubmed: 27386503
Neurology. 2021 Feb 9;96(6):e853-e865
pubmed: 33219142
Clin Rev Allergy Immunol. 2017 Dec;53(3):469-476
pubmed: 29116459
MAbs. 2018 Oct;10(7):1111-1130
pubmed: 30130439
Ann Rheum Dis. 2018 Sep;77(9):1345-1353
pubmed: 29895567
Crit Rev Biotechnol. 2015 Jun;35(2):235-54
pubmed: 24156398
J Intern Med. 2015 Oct;278(4):369-95
pubmed: 26212387
Nat Rev Immunol. 2002 Feb;2(2):85-95
pubmed: 11910899
Nat Med. 2008 Feb;14(2):170-5
pubmed: 18223654
Mol Ther. 2021 Mar 3;29(3):1312-1323
pubmed: 33212299
Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9337-42
pubmed: 18599440
Clin Exp Allergy. 2015 Jun;45(6):1085-98
pubmed: 25652137
Curr Opin Immunol. 2004 Dec;16(6):780-6
pubmed: 15511673
Sci Rep. 2020 Feb 28;10(1):3685
pubmed: 32111886
Am J Obstet Gynecol. 2019 May;220(5):498.e1-498.e9
pubmed: 30849355
Nat Commun. 2017 May 31;8:15314
pubmed: 28561044
Curr Opin Rheumatol. 2019 Nov;31(6):669-677
pubmed: 31415031
Gastroenterology. 2009 Nov;137(5):1746-56.e1
pubmed: 19664634
Sci Rep. 2018 Mar 23;8(1):5141
pubmed: 29572538
Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):967-72
pubmed: 18198272
Blood Adv. 2020 Sep 8;4(17):4136-4146
pubmed: 32886753
Nat Rev Immunol. 2007 Sep;7(9):715-25
pubmed: 17703228
Front Immunol. 2020 May 14;11:810
pubmed: 32477339
Front Immunol. 2016 Mar 09;7:86
pubmed: 27014266
Nat Biotechnol. 2005 Oct;23(10):1283-8
pubmed: 16186811
Nat Rev Genet. 2009 Jan;10(1):43-55
pubmed: 19092835
Immunity. 2004 Jun;20(6):769-83
pubmed: 15189741
J Immunol. 2007 Sep 1;179(5):2999-3011
pubmed: 17709515
J Immunol. 2011 Apr 15;186(8):4674-86
pubmed: 21402891
J Allergy Clin Immunol. 2020 Sep;146(3):492-500
pubmed: 32721416
J Exp Med. 2020 Oct 5;217(10):
pubmed: 32658257
J Clin Med. 2021 Feb 16;10(4):
pubmed: 33669423
J Immunol. 1996 Oct 15;157(8):3317-22
pubmed: 8871627
Microorganisms. 2021 Apr 20;9(4):
pubmed: 33923917
Ann Rheum Dis. 2019 Jun;78(6):736-745
pubmed: 30926722
Clin Exp Immunol. 2013 Feb;171(2):186-94
pubmed: 23286945
PLoS One. 2012;7(5):e35296
pubmed: 22662108
Sci Transl Med. 2017 Nov 1;9(414):
pubmed: 29093180
J Clin Invest. 2004 May;113(9):1328-33
pubmed: 15124024
J Clin Invest. 2018 Oct 1;128(10):4372-4386
pubmed: 30040076
J Invest Dermatol. 2011 Nov;131(11):2271-80
pubmed: 21697892
J Neurol. 2016 Aug;263(8):1473-94
pubmed: 26886206
Blood. 2020 Jun 4;135(23):2085-2093
pubmed: 32187355
Blood. 2015 Apr 9;125(15):2397-404
pubmed: 25680756
Lupus. 2011 Nov;20(13):1396-403
pubmed: 22095887
Am J Physiol Renal Physiol. 2002 Feb;282(2):F358-65
pubmed: 11788451
Am J Hematol. 2020 Feb;95(2):178-187
pubmed: 31821591
Transgenic Res. 2007 Oct;16(5):613-27
pubmed: 17594529
Bull NYU Hosp Jt Dis. 2009;67(3):251-3
pubmed: 19852746
Nephron. 2016;134(4):272-282
pubmed: 27560625
PLoS One. 2020 Dec 28;15(12):e0230401
pubmed: 33370294
Clin Pharmacol Ther. 2019 Apr;105(4):1031-1039
pubmed: 30402880
Cancer Med. 2020 Jul;9(13):4736-4742
pubmed: 32368865
Autoimmun Rev. 2019 Oct;18(10):102366
pubmed: 31404703
J Immunol. 2015 Jun 1;194(11):5497-508
pubmed: 25904551
Immunol Rev. 2015 Nov;268(1):269-87
pubmed: 26497527
Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17110-5
pubmed: 25406323
J Am Soc Nephrol. 2014 May;25(5):918-25
pubmed: 24357670
J Am Soc Nephrol. 2000 Apr;11(4):632-639
pubmed: 10752522
Semin Arthritis Rheum. 2004 Oct;34(2):501-37
pubmed: 15505768
Int J Mol Sci. 2021 Mar 17;22(6):
pubmed: 33802650
Clin Infect Dis. 2010 Dec 15;51(12):1355-61
pubmed: 21058908
MAbs. 2013 Jul-Aug;5(4):614-9
pubmed: 23751752
J Exp Med. 1997 Aug 29;186(5):777-83
pubmed: 9271593
Front Immunol. 2020 Aug 21;11:1887
pubmed: 32973781
Nature. 1964 Sep 26;203:1352-4
pubmed: 14207307
N Engl J Med. 2003 Oct 16;349(16):1526-33
pubmed: 14561795
Front Immunol. 2020 Jun 09;11:1153
pubmed: 32582216
Immunology. 2006 Sep;119(1):83-9
pubmed: 16805790
Clin Exp Rheumatol. 2009 Jul-Aug;27(4):609-14
pubmed: 19772792
Int Immunopharmacol. 2017 Mar;44:53-60
pubmed: 28081504
Arthritis Res Ther. 2013 Mar 27;15(2):R47
pubmed: 23531237
Trends Pharmacol Sci. 2018 Oct;39(10):892-904
pubmed: 30143244
Mol Immunol. 2015 Oct;67(2 Pt A):131-41
pubmed: 25766596
Allergy. 2020 Dec;75(12):3208-3215
pubmed: 32446275
Ann N Y Acad Sci. 2003 Apr;987:140-9
pubmed: 12727633
Front Neurol. 2021 Apr 14;12:664664
pubmed: 33935958
Sci Adv. 2019 Dec 18;5(12):eaax9586
pubmed: 31897428
Front Immunol. 2021 Jan 28;11:602823
pubmed: 33584670
J Immunol. 2008 Jul 1;181(1):449-63
pubmed: 18566411
Proc Natl Acad Sci U S A. 1996 May 28;93(11):5512-6
pubmed: 8643606
Neurology. 2019 Jun 4;92(23):e2661-e2673
pubmed: 31118245
Sci Transl Med. 2016 Nov 16;8(365):365ra158
pubmed: 27856797
MAbs. 2011 Mar-Apr;3(2):173-80
pubmed: 21239891
Ther Adv Neurol Disord. 2021 Feb 26;14:1756286421997381
pubmed: 33717213
Blood. 2006 Nov 15;108(10):3573-9
pubmed: 16849638
J Immunol. 2011 Nov 1;187(9):4695-704
pubmed: 21964024
Ann Rheum Dis. 2020 Jun;79(6):685-699
pubmed: 31969328
J Autoimmun. 2005 Dec;25(4):272-82
pubmed: 16242913
Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9927-32
pubmed: 21628593
Haematologica. 2015 Nov;100(11):1388-95
pubmed: 26521297
PLoS One. 2012;7(1):e28869
pubmed: 22247762
Clin Transl Sci. 2021 Mar 20;:
pubmed: 33742786
PLoS One. 2012;7(4):e36286
pubmed: 22558422
Clin Exp Immunol. 2019 Apr;196(1):12-27
pubmed: 30589082
Blood. 2017 May 25;129(21):2864-2872
pubmed: 28416511
Nat Rev Rheumatol. 2016 Nov 22;12(12):716-730
pubmed: 27872476