Cutaneous solitary fibrous tumor: Report of three cases with review of histopathological mimics.
cutaneous
immunohistochemistry
solitary fibrous tumor
spindle cell neoplasm
Journal
Journal of cutaneous pathology
ISSN: 1600-0560
Titre abrégé: J Cutan Pathol
Pays: United States
ID NLM: 0425124
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
revised:
13
09
2021
received:
30
05
2021
accepted:
22
09
2021
pubmed:
28
9
2021
medline:
29
3
2022
entrez:
27
9
2021
Statut:
ppublish
Résumé
Solitary fibrous tumor (SFT) is a relatively uncommon spindle cell mesenchymal neoplasm that is most often based on the pleura but may rarely arise in extrapleural locations, including the skin. Herein, we describe three cases of cutaneous SFTs. SFT is characterized by epithelioid and spindle cells arranged in random patterns with focal prominent stromal collagen and pericytomatous vessels. Immunohistochemical evaluation is required for definitive distinction of SFT from other benign and malignant cutaneous spindle cell neoplasms. Although aggressive biologic behavior is uncommon, accurate diagnosis of it is required for prognostication and counseling. CD34, bcl-2, and CD99 stains are positive in SFT, but not specific. STAT6 is the most sensitive and specific immunohistochemical marker to confirm diagnosis of SFT.
Substances chimiques
STAT6 Transcription Factor
0
STAT6 protein, human
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
167-171Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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