Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities.
amyloid
cognition
comorbid conditions
demographics
neurofilament light chain
total tau
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
24
06
2021
received:
08
04
2021
accepted:
25
06
2021
pubmed:
28
9
2021
medline:
9
6
2022
entrez:
27
9
2021
Statut:
ppublish
Résumé
Blood-based biomarkers of amyloid pathology and neurodegeneration are entering clinical use. It is critical to understand what factors affect the levels of these markers. Plasma markers (Aβ42, Aβ40, NfL, T-tau, Aβ42/40 ratio) were measured on the Quanterix Simoa HD-1 analyzer for 996 Mayo Clinic Study of Aging (MCSA) participants, aged 51 to 95 years. All other data were collected during in-person MCSA visits or abstracted from the medical record. Among cognitively unimpaired (CU) participants, all plasma markers correlated with age. Linear regression models revealed multiple relationships. For example, higher Charlson Comorbidity Index and chronic kidney disease were associated with higher levels of all biomarkers. Some relationships differed between mild cognitive impairment and dementia participants. Multiple variables affect plasma biomarkers of amyloid pathology and neurodegeneration among CU in the general population. Incorporating this information is critical for accurate interpretation of the biomarker levels and for the development of reference ranges.
Identifiants
pubmed: 34569696
doi: 10.1002/alz.12466
pmc: PMC8957642
mid: NIHMS1733068
doi:
Substances chimiques
Amyloid
0
Amyloid beta-Peptides
0
Amyloidogenic Proteins
0
Biomarkers
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1128-1140Subventions
Organisme : NIA NIH HHS
ID : R01 AG034676
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG011378
Pays : United States
Organisme : NIA NIH HHS
ID : R33 AG058738
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097495
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062677
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG011378
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 the Alzheimer's Association.
Références
Brain Commun. 2020 Oct 06;2(2):fcaa166
pubmed: 33381755
J Nucl Med. 2009 Mar;50(3):348-55
pubmed: 19223409
J Intern Med. 2004 Sep;256(3):183-94
pubmed: 15324362
Brain. 2008 Mar;131(Pt 3):665-80
pubmed: 18263627
Alzheimers Res Ther. 2020 Dec 5;12(1):162
pubmed: 33278904
Sci Rep. 2016 May 31;6:26801
pubmed: 27241045
Brain. 2020 Apr 1;143(4):1220-1232
pubmed: 32206776
JAMA. 2018 Jun 19;319(23):2419-2429
pubmed: 29922829
J Nucl Med. 2009 Jun;50(6):878-86
pubmed: 19443597
Mayo Clin Proc. 2012 Feb;87(2):151-60
pubmed: 22305027
Neurology. 2016 Oct 25;87(17):1827-1835
pubmed: 27694257
Brain. 2020 Dec 5;143(11):3234-3241
pubmed: 33068398
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Alzheimers Res Ther. 2018 Jul 28;10(1):71
pubmed: 30055655
J Appl Lab Med. 2020 Jan 1;5(1):158-169
pubmed: 31811073
Alzheimers Dement. 2019 Jun;15(6):764-775
pubmed: 31113759
Nat Commun. 2020 Feb 10;11(1):812
pubmed: 32041951
Neurology. 2019 Jul 16;93(3):e252-e260
pubmed: 31182505
Alzheimers Dement. 2017 Jan;13(1):45-58
pubmed: 27870940
Neuroepidemiology. 2008;30(1):58-69
pubmed: 18259084
Front Cell Neurosci. 2019 Feb 05;13:17
pubmed: 30804755
J Chronic Dis. 1987;40(5):373-83
pubmed: 3558716
Alzheimers Res Ther. 2020 Nov 12;12(1):147
pubmed: 33183357
J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):393-399
pubmed: 29244090
Neurology. 2021 May 5;:
pubmed: 33952656
Circulation. 1977 Oct;56(4 Pt 1):605-12
pubmed: 902387
Int J Epidemiol. 2012 Dec;41(6):1614-24
pubmed: 23159830
JAMA Neurol. 2019 May 1;76(5):598-606
pubmed: 30830207
J Am Soc Nephrol. 2011 Jul;22(7):1327-34
pubmed: 21700831
Alzheimers Dement. 2016 Dec;12(12):1226-1234
pubmed: 27436677
Alzheimers Dement. 2017 Mar;13(3):205-216
pubmed: 27697430
Brain. 2021 Mar 3;144(2):434-449
pubmed: 33479777
J Cereb Blood Flow Metab. 2005 Nov;25(11):1528-47
pubmed: 15944649
JAMA Neurol. 2017 May 1;74(5):557-566
pubmed: 28346578
Ann Neurol. 2017 Jun;81(6):857-870
pubmed: 28512753
J Alzheimers Dis. 2018;66(3):1235-1244
pubmed: 30412489
Ann Clin Transl Neurol. 2020 Jan;7(1):139-143
pubmed: 31893563