Transformable Helical Self-Assembly for Cancerous Golgi Apparatus Disruption.

Golgi Apparatus Humans Nanoparticles Neoplasms / drug therapy
Golgi apparatus cancer helical fibrils mechanical disruption peptide self-assembly

Journal

Nano letters
ISSN: 1530-6992
Titre abrégé: Nano Lett
Pays: United States
ID NLM: 101088070

Informations de publication

Date de publication:
13 10 2021
Historique:
pubmed: 28 9 2021
medline: 15 10 2021
entrez: 27 9 2021
Statut: ppublish

Résumé

Golgi apparatus is a major subcellular organelle responsible for drug resistance. Golgi apparatus-targeted nanomechanical disruption provides an attractive approach for killing cancer cells by multimodal mechanism and avoiding drug resistance. Inspired by the poisonous twisted fibrils in Alzheimer's brain tissue and enhanced rigidity of helical structure in nature, we designed transformable peptide C

Identifiants

DOI: 10.1021/acs.nanolett.1c03112 PMID: 34569805
pubmed: 34569805
doi: 10.1021/acs.nanolett.1c03112
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8455-8465

Auteurs

Rong Sheng Li (RS)

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China.
Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China.
ORCID: 0000-0001-5253-4053

Jiahui Liu (J)

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China.

Hu Shi (H)

School of Chemistry and Chemical Engineering and Institute of Molecular Science, Shanxi University, Taiyuan 030006, P.R. China.
ORCID: 0000-0002-5466-5783

Ping Ping Hu (PP)

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, P.R. China.
ORCID: 0000-0002-8880-362X

Yao Wang (Y)

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China.

Peng Fei Gao (PF)

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China.
ORCID: 0000-0001-6878-6597

Jian Wang (J)

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China.
ORCID: 0000-0002-9292-0810

Moye Jia (M)

Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China.

Hongwei Li (H)

Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China.

Yuan Fang Li (YF)

Key Laboratory of Luminescence and Real-Time Analytical System, Chongqing Science and Technology Bureau, College of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P.R. China.
ORCID: 0000-0001-5710-4423

Chengde Mao (C)

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China.
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 United States.
ORCID: 0000-0001-7516-8666

Na Li (N)

Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China.
ORCID: 0000-0002-1496-8798

Cheng Zhi Huang (CZ)

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China.
ORCID: 0000-0002-1260-5934

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Appareil de Golgi › Transformable Helical Self-Assembly for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Transformable Helical Self-Assembly for...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Transformable Helical Self-Assembly for...
questionsmedicales.fr › Tumeurs › Transformable Helical Self-Assembly for...