miRNATissueAtlas2: an update to the human miRNA tissue atlas.
Animals
Atlases as Topic
Female
Humans
Internet
Male
Mice
MicroRNAs
/ classification
Organ Specificity
RNA, Long Noncoding
/ classification
RNA, Small Interfering
/ classification
RNA, Small Nuclear
/ classification
RNA, Small Nucleolar
/ classification
RNA, Transfer
/ classification
Software
Transcriptome
Journal
Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011
Informations de publication
Date de publication:
07 01 2022
07 01 2022
Historique:
accepted:
07
09
2021
revised:
26
08
2021
received:
08
07
2021
pubmed:
28
9
2021
medline:
23
2
2022
entrez:
27
9
2021
Statut:
ppublish
Résumé
Small non-coding RNAs (sncRNAs) are pervasive regulators of physiological and pathological processes. We previously developed the human miRNA Tissue Atlas, detailing the expression of miRNAs across organs in the human body. Here, we present an updated resource containing sequencing data of 188 tissue samples comprising 21 organ types retrieved from six humans. Sampling the organs from the same bodies minimizes intra-individual variability and facilitates the making of a precise high-resolution body map of the non-coding transcriptome. The data allow shedding light on the organ- and organ system-specificity of piwi-interacting RNAs (piRNAs), transfer RNAs (tRNAs), microRNAs (miRNAs) and other non-coding RNAs. As use case of our resource, we describe the identification of highly specific ncRNAs in different organs. The update also contains 58 samples from six tissues of the Tabula Muris collection, allowing to check if the tissue specificity is evolutionary conserved between Homo sapiens and Mus musculus. The updated resource of 87 252 non-coding RNAs from nine non-coding RNA classes for all organs and organ systems is available online without any restrictions (https://www.ccb.uni-saarland.de/tissueatlas2).
Identifiants
pubmed: 34570238
pii: 6376029
doi: 10.1093/nar/gkab808
pmc: PMC8728130
doi:
Substances chimiques
MicroRNAs
0
RNA, Long Noncoding
0
RNA, Small Interfering
0
RNA, Small Nuclear
0
RNA, Small Nucleolar
0
RNA, Transfer
9014-25-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
D211-D221Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.
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