Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome.
Journal
PLoS pathogens
ISSN: 1553-7374
Titre abrégé: PLoS Pathog
Pays: United States
ID NLM: 101238921
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
07
01
2021
accepted:
28
07
2021
revised:
07
10
2021
pubmed:
28
9
2021
medline:
25
11
2021
entrez:
27
9
2021
Statut:
epublish
Résumé
During replication, RNA viruses accumulate genome alterations, such as mutations and deletions. The interactions between individual variants can determine the fitness of the virus population and, thus, the outcome of infection. To investigate the effects of defective interfering genomes (DI) on wild-type (WT) poliovirus replication, we developed an ordinary differential equation model, which enables exploring the parameter space of the WT and DI competition. We also experimentally examined virus and DI replication kinetics during co-infection, and used these data to infer model parameters. Our model identifies, and our experimental measurements confirm, that the efficiencies of DI genome replication and encapsidation are two most critical parameters determining the outcome of WT replication. However, an equilibrium can be established which enables WT to replicate, albeit to reduced levels.
Identifiants
pubmed: 34570820
doi: 10.1371/journal.ppat.1009277
pii: PPATHOGENS-D-21-00004
pmc: PMC8496841
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1009277Subventions
Organisme : NIAID NIH HHS
ID : R41 AI157129
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008284
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI040085
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI144144
Pays : United States
Organisme : NIAID NIH HHS
ID : R41 AI155100
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI036178
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI060537
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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