Triptycene derivatives as chiral probes for studying the molecular enantiorecognition on sub-2-μm particle cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase.
absolute configuration
cellulose-based CSP
chiralpak IB-U
hydrogen bonding
triptycene
ultrafast enantioselectivity
Journal
Chirality
ISSN: 1520-636X
Titre abrégé: Chirality
Pays: United States
ID NLM: 8914261
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
04
08
2021
received:
25
06
2021
accepted:
26
08
2021
pubmed:
28
9
2021
medline:
28
9
2021
entrez:
27
9
2021
Statut:
ppublish
Résumé
Two chiral triptycene derivatives were analyzed on the Chiralpak IB-U column packed with cellulose tris(3,5-dimethylphenylcarbamate)-based sub-2-μm diameter particles. Under normal-phase conditions, sub-minute baseline enantioseparations were obtained. Differences in structural elements and chromatographic behavior of the investigated compounds were evaluated to identify the interactions that drive the chiral discrimination process. From the evaluation of the experimental chromatographic data, it was found that hydrogen bond formation is essential for the separation of enantiomers.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
883-890Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
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