Sphingolipids: Effectors and Achilles Heals in Viral Infections?
Biological Transport
Cell Membrane
/ chemistry
Ceramides
/ metabolism
Drug Delivery Systems
HIV
/ growth & development
Host Microbial Interactions
Intracellular Membranes
/ chemistry
SARS-CoV-2
/ growth & development
Sphingolipids
/ metabolism
Virion
Virus Diseases
Virus Replication
Viruses
/ growth & development
HIV
SARS-CoV-2
ceramides
glycosphingolipids
measles
sphingomyelinase
sphingosine 1-phosphate
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
24 08 2021
24 08 2021
Historique:
received:
02
08
2021
revised:
16
08
2021
accepted:
20
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
9
10
2021
Statut:
epublish
Résumé
As viruses are obligatory intracellular parasites, any step during their life cycle strictly depends on successful interaction with their particular host cells. In particular, their interaction with cellular membranes is of crucial importance for most steps in the viral replication cycle. Such interactions are initiated by uptake of viral particles and subsequent trafficking to intracellular compartments to access their replication compartments which provide a spatially confined environment concentrating viral and cellular components, and subsequently, employ cellular membranes for assembly and exit of viral progeny. The ability of viruses to actively modulate lipid composition such as sphingolipids (SLs) is essential for successful completion of the viral life cycle. In addition to their structural and biophysical properties of cellular membranes, some sphingolipid (SL) species are bioactive and as such, take part in cellular signaling processes involved in regulating viral replication. It is especially due to the progress made in tools to study accumulation and dynamics of SLs, which visualize their compartmentalization and identify interaction partners at a cellular level, as well as the availability of genetic knockout systems, that the role of particular SL species in the viral replication process can be analyzed and, most importantly, be explored as targets for therapeutic intervention.
Identifiants
pubmed: 34571822
pii: cells10092175
doi: 10.3390/cells10092175
pmc: PMC8466362
pii:
doi:
Substances chimiques
Ceramides
0
Sphingolipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK2581
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