Multi Species Analyses Reveal Testicular T3 Metabolism and Signalling as a Target of Environmental Pesticides.
Animals
Cell Differentiation
/ drug effects
Germ Cells
/ drug effects
Male
Mice
Mice, Inbred C57BL
Pesticides
/ pharmacology
Reproduction
/ drug effects
Seminiferous Tubules
/ drug effects
Signal Transduction
/ drug effects
Spermatogenesis
/ drug effects
Testis
/ diagnostic imaging
Thyroid Hormones
/ metabolism
Zebrafish
/ metabolism
T3 signalling and metabolism
cross-species analysis
fertility
pesticides
testis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
25 08 2021
25 08 2021
Historique:
received:
20
05
2021
revised:
20
08
2021
accepted:
22
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
20
11
2021
Statut:
epublish
Résumé
Thyroid hormones (THs) regulate many biological processes in vertebrates, including reproduction. Testicular somatic and germ cells are equipped with the arrays of enzymes (deiodinases), transporters, and receptors necessary to locally maintain the optimal level of THs and their signalling, needed for their functions and spermatogenesis. Pesticides, as chlorpyrifos (CPF) and ethylene thiourea (ETU), impair the function of thyroid and testis, affecting male fertility. However, their ability to disarrange testicular T3 (t-T3) metabolism and signalling is poorly considered. Here, a multi-species analysis involving zebrafish and mouse suggests the damage of t-T3 metabolism and signalling as a mechanism of gonadic toxicity of low-doses CPF and ETU. Indeed, the developmental exposure to both compounds reduces
Identifiants
pubmed: 34571837
pii: cells10092187
doi: 10.3390/cells10092187
pmc: PMC8471965
pii:
doi:
Substances chimiques
Pesticides
0
Thyroid Hormones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Regione Campania
ID : grant no 23
Organisme : Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro
ID : grant no 12010
Organisme : Regione Campania
ID : POR Campania FESR 2014/2020
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