The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis.
Animals
Cell Differentiation
/ physiology
Female
Heart
/ physiology
Male
Membrane Proteins
/ metabolism
Mice
Morphogenesis
/ physiology
Myocardium
/ metabolism
Nerve Tissue Proteins
/ metabolism
Organogenesis
/ physiology
Receptor, Notch1
/ metabolism
Signal Transduction
/ physiology
Stem Cells
/ metabolism
cardiac progenitor cell differentiation
cardiomyocyte proliferation
notch signaling
numb family proteins
outflow tract
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
25 08 2021
25 08 2021
Historique:
received:
29
07
2021
revised:
18
08
2021
accepted:
21
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
20
11
2021
Statut:
epublish
Résumé
Numb family proteins (NFPs), including Numb and Numblike (Numbl), are commonly known for their role as cell fate determinants for multiple types of progenitor cells, mainly due to their function as Notch inhibitors. Previous studies have shown that myocardial NFP double knockout (MDKO) hearts display an up-regulated Notch activation and various defects in cardiac progenitor cell differentiation and cardiac morphogenesis. Whether enhanced Notch activation causes these defects in MDKO is not fully clear. To answer the question, we examined the spatiotemporal patterns of Notch1 expression, Notch activation, and Numb expression in the murine embryonic hearts using multiple approaches including RNAScope, and Numb and Notch reporter mouse lines. To further interrogate the interaction between NFPs and Notch signaling activation, we deleted both
Identifiants
pubmed: 34571841
pii: cells10092192
doi: 10.3390/cells10092192
pmc: PMC8471136
pii:
doi:
Substances chimiques
Membrane Proteins
0
Nerve Tissue Proteins
0
Notch1 protein, mouse
0
Numb protein, mouse
0
Receptor, Notch1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL121700
Pays : United States
Organisme : American Heart Association
ID : 20TPA35490051
Organisme : NHLBI NIH HHS
ID : 2R01HL121700-06A1
Pays : United States
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