Alpha-Linolenic Acid Impedes Cadmium-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration in Mouse Brain.
Animals
Antioxidants
/ pharmacology
Apoptosis
Cadmium
/ toxicity
Gene Expression Regulation
/ drug effects
Heme Oxygenase-1
/ genetics
Inflammation
/ chemically induced
JNK Mitogen-Activated Protein Kinases
/ genetics
Male
Mice
Mice, Inbred C57BL
NF-E2-Related Factor 2
/ genetics
NF-kappa B
/ genetics
Neurodegenerative Diseases
/ chemically induced
Neuroprotective Agents
/ pharmacology
Oxidative Stress
/ drug effects
alpha-Linolenic Acid
/ pharmacology
Alpha Linolenic acid
Nrf2/HO-1
cadmium
neurodegeneration
neuroinflammation
neuroprotection
p-JNK
reactive oxygen species (ROS)
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
01 09 2021
01 09 2021
Historique:
received:
24
07
2021
revised:
16
08
2021
accepted:
23
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Alpha-Linolenic acid (ALA), an omega-3 polyunsaturated fatty acid, is extracted from plant sources and has been shown to be one of the anti-inflammatory and antioxidant agents. Herein, we revealed the molecular mechanism underlying the anti-inflammatory and antioxidant potential of (ALA), against cadmium in the adult mouse brain. We evaluated the neuroprotective effect of ALA (60 mg/kg per oral for 6 weeks) against CdCl
Identifiants
pubmed: 34571925
pii: cells10092274
doi: 10.3390/cells10092274
pmc: PMC8467071
pii:
doi:
Substances chimiques
Antioxidants
0
NF-E2-Related Factor 2
0
NF-kappa B
0
Neuroprotective Agents
0
Cadmium
00BH33GNGH
alpha-Linolenic Acid
0RBV727H71
Heme Oxygenase-1
EC 1.14.14.18
JNK Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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