Animals
Autophagy
Cyclic AMP Response Element-Binding Protein
/ antagonists & inhibitors
Diabetes Mellitus, Experimental
/ complications
Fruit
/ chemistry
Kruppel-Like Transcription Factors
/ antagonists & inhibitors
Lysosomes
/ drug effects
Male
Mice
Mice, Inbred C57BL
Muscular Atrophy
/ drug therapy
Plant Extracts
/ pharmacology
Schisandra
/ chemistry
Schisandrae chinensis Fructus
muscle protein degradation
muscle wasting
streptozotocin-induced diabetic mice
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 09 2021
02 09 2021
Historique:
received:
27
07
2021
revised:
29
08
2021
accepted:
31
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Type 1 diabetes mellitus is an autoimmune disease caused by the destruction of pancreatic beta cells. Many patients with type 1 diabetes experience skeletal muscle wasting. Although the link between type 1 diabetes and muscle wasting is not clearly known, insulin insufficiency and hyperglycemia may contribute to decreased muscle mass. In this study, we investigated the therapeutic effect of the ethanolic extract of
Identifiants
pubmed: 34571935
pii: cells10092283
doi: 10.3390/cells10092283
pmc: PMC8469055
pii:
doi:
Substances chimiques
Creb1 protein, mouse
0
Cyclic AMP Response Element-Binding Protein
0
Klf15 protein, mouse
0
Kruppel-Like Transcription Factors
0
Plant Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Korea Health Industry Development Institute
ID : HR14C0001
Organisme : National Research Foundation of Korea
ID : NRF-2020R1I1A1A01058279
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