Human Neural Stem Cells for Cell-Based Medicinal Products.
NSC
advanced therapies
central nervous system
efficacy
neural precursors
neural progenitors
quality control
regenerative medicine
safety
scalability
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
09 09 2021
09 09 2021
Historique:
received:
13
08
2021
revised:
01
09
2021
accepted:
03
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
18
11
2021
Statut:
epublish
Résumé
Neural stem cells represent an attractive tool for the development of regenerative therapies and are being tested in clinical trials for several neurological disorders. Human neural stem cells can be isolated from the central nervous system or can be derived in vitro from pluripotent stem cells. Embryonic sources are ethically controversial and other sources are less well characterized and/or inefficient. Recently, isolation of NSC from the cerebrospinal fluid of patients with spina bifida and with intracerebroventricular hemorrhage has been reported. Direct reprogramming may become another alternative if genetic and phenotypic stability of the reprogrammed cells is ensured. Here, we discuss the advantages and disadvantages of available sources of neural stem cells for the production of cell-based therapies for clinical applications. We review available safety and efficacy clinical data and discuss scalability and quality control considerations for manufacturing clinical grade cell products for successful clinical application.
Identifiants
pubmed: 34572024
pii: cells10092377
doi: 10.3390/cells10092377
pmc: PMC8469920
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundación Alicia Koplowitz
ID : PI19/00778
Organisme : Instituto de Salud Carlos III
ID : DTS20/00108
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