Sexually Dimorphic Transcriptomic Changes of Developing Fetal Brain Reveal Signaling Pathways and Marker Genes of Brain Cells in Domestic Pigs.
brain development
fetal sex
gene regulation
placenta
swine
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
16 09 2021
16 09 2021
Historique:
received:
17
08
2021
revised:
09
09
2021
accepted:
11
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
16
11
2021
Statut:
epublish
Résumé
In this study, transcriptomic changes of the developing brain of pig fetuses of both sexes were investigated on gestation days (GD) 45, 60 and 90. Pig fetal brain grows rapidly around GD60. Consequently, gene expression of the fetal brain was distinctly different on GD90 compared to that of GD45 and GD60. In addition, varying numbers of differentially expressed genes (DEGs) were identified in the male brain compared to the female brain during development. The sex of adjacent fetuses also influenced gene expression of the fetal brain. Extensive changes in gene expression at the exon-level were observed during brain development. Pathway enrichment analysis showed that the ionotropic glutamate receptor pathway and
Identifiants
pubmed: 34572090
pii: cells10092439
doi: 10.3390/cells10092439
pmc: PMC8466205
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15667-8
pubmed: 21890794
Brain Res Bull. 2005 Sep 15;66(4-6):484-90
pubmed: 16144637
J Anim Sci. 1989 Jul;67(7):1824-40
pubmed: 2670873
Clin Exp Nephrol. 2011 Aug;15(4):478-85
pubmed: 21611756
Genome Biol. 2013;14(10):R115
pubmed: 24138928
J Anim Sci. 2014 Oct;92(10):4400-6
pubmed: 25149341
BMC Bioinformatics. 2008 Oct 29;9:461
pubmed: 18959772
BMC Dev Biol. 2016 May 12;16:13
pubmed: 27175727
Front Mol Neurosci. 2018 Jun 05;11:197
pubmed: 29922129
Int J Biol Sci. 2019 Jul 25;15(9):2006-2015
pubmed: 31523200
Bioinformatics. 2002;18 Suppl 2:S231-40
pubmed: 12386007
Neurobiol Dis. 1998 Nov;5(5):305-22
pubmed: 10069574
J Clin Exp Neuropsychol. 1991 Nov;13(6):831-46
pubmed: 1779024
Neurosci Biobehav Rev. 2002 Oct;26(6):665-78
pubmed: 12479841
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Ann N Y Acad Sci. 2005 May;1049:161-71
pubmed: 15965115
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
Prenat Diagn. 2009 Apr;29(4):326-39
pubmed: 19003788
Philos Trans R Soc Lond B Biol Sci. 2016 Feb 19;371(1688):20150106
pubmed: 26833829
Mamm Genome. 2013 Dec;24(11-12):459-72
pubmed: 24249052
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10237-9
pubmed: 12149485
Physiol Rev. 2015 Jan;95(1):83-123
pubmed: 25540139
Aging (Albany NY). 2019 Aug 8;11(15):5412-5432
pubmed: 31395791
Neurosci Biobehav Rev. 2007;31(5):728-51
pubmed: 17445892
Dev Cogn Neurosci. 2019 Apr;36:100632
pubmed: 30901622
J Morphol. 2015 Aug;276(8):961-90
pubmed: 24652663
Database (Oxford). 2019 Jan 1;2019:
pubmed: 30951143
J Neuroendocrinol. 2010 Jul;22(7):743-53
pubmed: 20646175
Curr Neuropharmacol. 2016;14(6):619-26
pubmed: 26786146
Brain Behav Evol. 2011;78(3):248-57
pubmed: 21860220
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Neurochem Res. 2007 Oct;32(10):1730-40
pubmed: 17406975
Nat Protoc. 2013 Aug;8(8):1551-66
pubmed: 23868073
Neural Regen Res. 2019 Mar;14(3):413-424
pubmed: 30539807
J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):307-13
pubmed: 7626472
Neuroscience. 2015 Aug 20;301:363-74
pubmed: 26071959
J Biol Chem. 2003 Oct 31;278(44):43489-95
pubmed: 12923172
Int J Dev Biol. 2002 Jan;46(1):81-7
pubmed: 11902691
Pharmacol Res. 2019 Nov;149:104468
pubmed: 31600597
Curr Biol. 1995 Aug 1;5(8):931-6
pubmed: 7583151
Biol Reprod. 2018 Jul 1;99(1):196-211
pubmed: 29481584
Proc R Soc Lond B Biol Sci. 1967 Jan 24;166(1005):384-95
pubmed: 24796035
Biol Rev Camb Philos Soc. 2016 Aug;91(3):673-711
pubmed: 25925633
Reproduction. 2016 Nov;152(5):R179-89
pubmed: 27486265
Anat Embryol (Berl). 1988;177(5):409-19
pubmed: 3364745
Am J Hum Biol. 2010 Jul-Aug;22(4):431-43
pubmed: 19950190
Cell Mol Neurobiol. 1997 Dec;17(6):627-48
pubmed: 9442350
PLoS One. 2012;7(1):e30318
pubmed: 22272334
Biol Sex Differ. 2019 Sep 9;10(1):48
pubmed: 31500671
Pediatr Res. 2019 Aug;86(2):157-164
pubmed: 31003234
Clin Biochem Rev. 2017 Nov;38(3):131-142
pubmed: 29332977
Free Radic Biol Med. 2019 Mar;133:254-261
pubmed: 29981833
Prog Neurobiol. 2013 Jul-Aug;106-107:1-16
pubmed: 23583307
Am J Physiol Regul Integr Comp Physiol. 2004 Dec;287(6):R1505-16
pubmed: 15345472
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Dev Neurosci. 2012;34(4):291-8
pubmed: 22777003
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3251-3255
pubmed: 30718410
G3 (Bethesda). 2015 Nov 23;6(1):221-33
pubmed: 26596646
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23952-23959
pubmed: 32900950
Hum Exp Toxicol. 2002 Sep-Oct;21(9-10):533-6
pubmed: 12458912
Front Physiol. 2019 Jul 10;10:838
pubmed: 31354509
Cell Rep. 2019 Apr 9;27(2):442-454.e5
pubmed: 30970248
Brain Res Mol Brain Res. 2004 Jul 26;126(2):198-206
pubmed: 15249144
Nature. 2012 Nov 15;491(7424):393-8
pubmed: 23151582
Bioinformatics. 2015 Nov 15;31(22):3718-20
pubmed: 26209431
Nat Commun. 2016 Dec 06;7:13584
pubmed: 27922006
J Anim Sci. 1990 Jan;68(1):179-85
pubmed: 2303395
Psychopharmacology (Berl). 2017 Sep;234(18):2683-2696
pubmed: 28589265
Curr Opin Neurobiol. 2000 Jun;10(3):392-9
pubmed: 10851180
Nat Neurosci. 2021 Feb;24(2):204-213
pubmed: 33361822
Front Mol Biosci. 2018 Feb 12;5:12
pubmed: 29484299
Hum Reprod. 1987 Aug;2(6):517-20
pubmed: 3667908
Nat Methods. 2015 Apr;12(4):357-60
pubmed: 25751142
Front Neurosci. 2021 Jul 14;15:680214
pubmed: 34335160
Interdiscip Top Gerontol. 2015;40:74-84
pubmed: 25341514
FASEB J. 2019 Mar;33(3):4261-4272
pubmed: 30521381
Neurosci Lett. 2010 Oct 22;484(1):22-5
pubmed: 20708067
Curr Vasc Pharmacol. 2009 Oct;7(4):521-33
pubmed: 19485888
J Neurosci. 2006 Jan 18;26(3):757-62
pubmed: 16421295
Biom J. 2015 Sep;57(5):834-51
pubmed: 26147637
PLoS One. 2015 Apr 15;10(4):e0124295
pubmed: 25875176
Nat Genet. 1995 Jun;10(2):175-80
pubmed: 7663512
J Anim Sci. 2004 Sep;82(9):2534-40
pubmed: 15446468
Dev Psychopathol. 1999 Summer;11(3):395-417
pubmed: 10532616
Neuroscience. 2005;134(3):877-87
pubmed: 15994019
Biol Reprod. 2019 Jan 1;100(1):239-252
pubmed: 30137229
Dialogues Clin Neurosci. 2016 Dec;18(4):459-464
pubmed: 28179817
PLoS Genet. 2012 Sep;8(9):e1002962
pubmed: 23028369
Dialogues Clin Neurosci. 2016 Dec;18(4):361-372
pubmed: 28179808
Adv Nutr. 2017 Jan 17;8(1):92-104
pubmed: 28096130