Synapsin-Promoted Caveolin-1 Overexpression Maintains Mitochondrial Morphology and Function in PSAPP Alzheimer's Disease Mice.
Alzheimer Disease
/ etiology
Amyloid beta-Protein Precursor
/ genetics
Animals
Caveolin 1
/ genetics
Disease Models, Animal
Hippocampus
/ physiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mitochondria
/ physiology
Neurons
/ physiology
Neuroprotective Agents
/ administration & dosage
Phosphorylation
Presenilins
/ genetics
Synapsins
/ genetics
Alzheimer’s disease
caveolin
gene therapy
mitochondria
oxidative stress
transgenic
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
20 09 2021
20 09 2021
Historique:
received:
04
07
2021
revised:
15
09
2021
accepted:
17
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
23
11
2021
Statut:
epublish
Résumé
Mitochondrial dysfunction plays a pivotal role in the Alzheimer's Disease (AD) pathology. Disrupted mitochondrial dynamics (i.e., fusion/fission balance), which are essential for normal mitochondria structure and function, are documented in AD. Caveolin-1 (Cav-1), a membrane/lipid raft (MLR) scaffolding protein regulates metabolic pathways in several different cell types such as hepatocytes and cancer cells. Previously, we have shown decreased expression of Cav-1 in the hippocampus of 9-month (m) old PSAPP mice, while hippocampal overexpression of neuron-targeted Cav-1 using the synapsin promoter (i.e.,
Identifiants
pubmed: 34572135
pii: cells10092487
doi: 10.3390/cells10092487
pmc: PMC8467690
pii:
doi:
Substances chimiques
Amyloid beta-Protein Precursor
0
Caveolin 1
0
Neuroprotective Agents
0
Presenilins
0
Synapsins
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : BLRD VA
ID : I01 BX003671
Pays : United States
Organisme : BLRD VA
ID : IK6 BX005229
Pays : United States
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