Longitudinal Follow-Up of Blood Telomere Length in HIV-Exposed Uninfected Children Having Received One Year of Lopinavir/Ritonavir or Lamivudine as Prophylaxis.
Africa
HIV
children
growth
mitochondrial DNA
neuropsychological development
prophylaxis
telomere shortening
Journal
Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936
Informations de publication
Date de publication:
10 Sep 2021
10 Sep 2021
Historique:
received:
23
07
2021
revised:
27
08
2021
accepted:
30
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Telomere shortening can be enhanced upon human immunodeficiency virus (HIV) infection and by antiretroviral (ARV) exposures. The aim of this study was to evaluate the acute and long-term effect on telomere shortening of two ARV prophylaxes, lopinavir/ritonavir (LPV/r) and lamivudine (3TC), administered to children who are HIV-exposed uninfected (CHEU) to prevent HIV acquisition through breastfeeding during the first year of life, and to investigate the relationship between telomere shortening and health outcomes at six years of age. We included 198 CHEU and measured telomere length at seven days of life, at week-50 and at six years (year-6) using quantitative polymerase chain reaction. At week-50, telomere shortening was observed among 44.3% of CHEU, irrespective of the prophylactic treatment. Furthermore, this telomere shortening was neither associated with poor growth indicators nor neuropsychological outcomes at year-6, except for motor abilities (MABC test
Identifiants
pubmed: 34572228
pii: children8090796
doi: 10.3390/children8090796
pmc: PMC8468502
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Agence Nationale de Recherches sur le Sida et les Hépatites Virales
ID : ANRS#12274
Organisme : Agence Nationale de Recherches sur le Sida et les Hépatites Virales
ID : ANRS12174-B90
Organisme : European and Developing Countries Clinical Trials Partnership
ID : #CT.2006.33020.004
Organisme : Royal council of Norway
ID : GlobVac grant # 183600
Organisme : Pierre Bergé fundation
ID : AP-FPB-2013-2/09
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