Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer's Disease.
Alzheimer’s disease
C-reactive protein
CSF and plasma biomarkers
Parkinson’s disease
YKL-40
astrogliosis
inflammation
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
27 Aug 2021
27 Aug 2021
Historique:
received:
21
07
2021
revised:
16
08
2021
accepted:
23
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Neuroinflammation is a common feature in Alzheimer's (AD) and Parkinson's (PD) disease. In the last few decades, a testable hypothesis was proposed that protein-unfolding events might occur due to neuroinflammatory cascades involving alterations in the crosstalk between glial cells and neurons. Here, we tried to clarify the pattern of two of the most promising biomarkers of neuroinflammation in cerebrospinal fluid (CSF) in AD and PD. This study included cognitively unimpaired elderly patients, patients with mild cognitive impairment, patients with AD dementia, and patients with PD. CSF samples were analyzed for YKL-40 and C-reactive protein (CRP). We found that CSF YKL-40 levels were significantly increased only in dementia stages of AD. Additionally, increased YKL-40 levels were found in the cerebral orbitofrontal cortex from AD patients in agreement with augmented astrogliosis. Our study confirms that these biomarkers of neuroinflammation are differently detected in CSF from AD and PD patients.
Identifiants
pubmed: 34572280
pii: biomedicines9091094
doi: 10.3390/biomedicines9091094
pmc: PMC8467854
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : FIS18/00118
Organisme : Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
ID : CB07/502
Organisme : Instituto de Salud Carlos III
ID : CM 18/0095
Organisme : Consejería de Educación e Investigación
ID : S2017/BMD-3700
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