Cytoskeleton Response to Ionizing Radiation: A Brief Review on Adhesion and Migration Effects.

adhesion cancer cytoskeleton ionizing radiation mechanobiology migration

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
28 Aug 2021
Historique:
received: 15 07 2021
revised: 18 08 2021
accepted: 24 08 2021
entrez: 28 9 2021
pubmed: 29 9 2021
medline: 29 9 2021
Statut: epublish

Résumé

The cytoskeleton is involved in several biological processes, including adhesion, motility, and intracellular transport. Alterations in the cytoskeletal components (actin filaments, intermediate filaments, and microtubules) are strictly correlated to several diseases, such as cancer. Furthermore, alterations in the cytoskeletal structure can lead to anomalies in cells' properties and increase their invasiveness. This review aims to analyse several studies which have examined the alteration of the cell cytoskeleton induced by ionizing radiations. In particular, the radiation effects on the actin cytoskeleton, cell adhesion, and migration have been considered to gain a deeper knowledge of the biophysical properties of the cell. In fact, the results found in the analysed works can not only aid in developing new diagnostic tools but also improve the current cancer treatments.

Identifiants

pubmed: 34572287
pii: biomedicines9091102
doi: 10.3390/biomedicines9091102
pmc: PMC8465203
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Giuseppe La Verde (G)

Istituto Nazionale di Fisica Nucleare, INFN Sezione di Napoli, 80126 Naples, Italy.
Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.

Valeria Artiola (V)

Centro Servizi Metrologici e Tecnologici Avanzati, Università di Napoli Federico II, 80146 Naples, Italy.

Valeria Panzetta (V)

Centro di Ricerca Interdipartimentale sui Biomateriali (CRIB), Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Università degli Studi di Napoli Federico II, 80125 Naples, Italy.
Centre for Advanced Biomaterial for Health Care, Istituto Italiano di Tecnologia, 80125 Naples, Italy.

Mariagabriella Pugliese (M)

Istituto Nazionale di Fisica Nucleare, INFN Sezione di Napoli, 80126 Naples, Italy.
Dipartimento di Fisica "Ettore Pancini", Università degli Studi di Napoli Federico II, 80126 Naples, Italy.

Paolo A Netti (PA)

Centro di Ricerca Interdipartimentale sui Biomateriali (CRIB), Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Università degli Studi di Napoli Federico II, 80125 Naples, Italy.
Centre for Advanced Biomaterial for Health Care, Istituto Italiano di Tecnologia, 80125 Naples, Italy.

Sabato Fusco (S)

Dipartimento di Medicina e Scienze della Salute "Vincenzo Tiberio", Università del Molise, 86100 Campobasso, Italy.

Classifications MeSH