Role of Calcium Homeostasis in Modulating EMT in Cancer.
EMT
calcium
cancer
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
11 Sep 2021
11 Sep 2021
Historique:
received:
13
07
2021
revised:
04
09
2021
accepted:
06
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Calcium is essential for cells to perform numerous physiological processes. In cancer, the augmentation of calcium signaling supports the more proliferative and migratory cells, which is a characteristic of the epithelial-to-mesenchymal transition (EMT). By genetically and epigenetically modifying genes, channels, and entire signaling pathways, cancer cells have adapted to survive with an extreme imbalance of calcium that allows them to grow and metastasize in an abnormal manner. This cellular remodeling also allows for the evasion of immune surveillance and the development of drug resistance, which lead to poor prognosis in patients. Understanding the role calcium flux plays in driving the phenotypes associated with invasion, immune suppression, metastasis, and drug resistance remains critical for determining treatments to optimize clinical outcomes and future drug discovery.
Identifiants
pubmed: 34572386
pii: biomedicines9091200
doi: 10.3390/biomedicines9091200
pmc: PMC8471317
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : 5U54GM104942-04
Pays : United States
Références
Front Oncol. 2020 Jun 30;10:920
pubmed: 32695666
Clin Cancer Res. 2016 Jul 15;22(14):3422-4
pubmed: 27076625
BMC Cancer. 2019 Jul 31;19(1):751
pubmed: 31366337
Ther Adv Med Oncol. 2012 Jul;4(4):173-81
pubmed: 22754591
Front Physiol. 2016 May 26;7:190
pubmed: 27303307
Int J Mol Sci. 2019 Jun 20;20(12):
pubmed: 31226817
Gut Liver. 2016 May 23;10(3):340-7
pubmed: 27114434
Front Oncol. 2019 Oct 11;9:1044
pubmed: 31681582
Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H446-58
pubmed: 23792674
J Biol Chem. 1991 Mar 5;266(7):4471-7
pubmed: 1705553
Med Oncol. 2013;30(3):607
pubmed: 23686700
Int J Mol Sci. 2020 Jun 11;21(11):
pubmed: 32545311
Cell Calcium. 2007 Aug;42(2):205-11
pubmed: 17517433
Mediators Inflamm. 2021 Mar 2;2021:6655417
pubmed: 33746610
Cell. 2010 Apr 2;141(1):69-80
pubmed: 20371346
Br J Pharmacol. 2013 Oct;170(3):459-74
pubmed: 23763262
Cell Signal. 2012 Jan;24(1):162-9
pubmed: 21924350
Eur J Pharmacol. 2005 May 16;515(1-3):20-7
pubmed: 15913603
Neuro Oncol. 2017 Jun 1;19(6):845-852
pubmed: 28371832
Oncoimmunology. 2017 Sep 27;7(1):e1376155
pubmed: 29296536
Cell Calcium. 2020 Jan;85:102109
pubmed: 31783287
Contrast Media Mol Imaging. 2018 Dec 9;2018:9840962
pubmed: 30627063
Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2502-11
pubmed: 25150047
Int J Mol Sci. 2020 Mar 03;21(5):
pubmed: 32138386
Adv Biol Regul. 2013 Sep;53(3):341-55
pubmed: 23916247
Cancer Drug Resist. 2020;3(1):38-47
pubmed: 32226927
Int J Mol Sci. 2016 Aug 12;17(8):
pubmed: 27529230
Mol Cancer Res. 2018 Nov;16(11):1773-1784
pubmed: 29967110
Immunol Rev. 2019 May;289(1):205-231
pubmed: 30977203
Cell Calcium. 2019 Jun;80:141-151
pubmed: 31103948
BMC Endocr Disord. 2020 Jun 30;20(1):97
pubmed: 32605565
Front Pharmacol. 2021 Jan 13;11:539261
pubmed: 33519429
Breast Cancer Res. 2019 Mar 7;21(1):37
pubmed: 30845991
Int J Clin Exp Pathol. 2015 May 01;8(5):5080-8
pubmed: 26191202
J Cell Biol. 1994 Feb;124(4):619-26
pubmed: 8106557
Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1092-7
pubmed: 26755577
Adv Nutr. 2019 May 1;10(3):546-548
pubmed: 30915443
Nat Commun. 2016 Dec 02;7:13297
pubmed: 27910855
Cancer Lett. 2020 Jan 1;468:72-81
pubmed: 31605776
Sci Rep. 2017 Nov 22;7(1):16012
pubmed: 29167562
J Biol Chem. 2017 Sep 15;292(37):15525-15537
pubmed: 28768769
Oncotarget. 2018 Jun 29;9(50):29468-29483
pubmed: 30034631
Sci Rep. 2020 Aug 25;10(1):14181
pubmed: 32843670
J Cell Sci. 2011 May 15;124(Pt 10):1672-80
pubmed: 21511727
Cancer Cell. 2011 Apr 12;19(4):541-55
pubmed: 21481794
Cancer Res. 2016 Mar 15;76(6):1494-505
pubmed: 26719529
Breast Cancer (Auckl). 2018 Aug 01;12:1178223418788074
pubmed: 30083055
Cell Cycle. 2010 Feb 15;9(4):623-4
pubmed: 20107326
Front Oncol. 2019 Jul 10;9:626
pubmed: 31355143
Nat Commun. 2018 May 15;9(1):1908
pubmed: 29765039
Sci Rep. 2019 Sep 19;9(1):13579
pubmed: 31537872
Cancer Metastasis Rev. 2018 Mar;37(1):173-187
pubmed: 29322354
Cell Death Dis. 2017 Aug 24;8(8):e3007
pubmed: 28837141
Cancer Biol Ther. 2004 Dec;3(12):1243-9
pubmed: 15611621
Oncogene. 2013 Sep 19;32(38):4529-38
pubmed: 23108402
Nat Med. 2019 Oct;25(10):1470-1471
pubmed: 31591604
J Physiol. 2018 Jul;596(14):2681-2698
pubmed: 29368348
Sci Rep. 2019 Nov 27;9(1):17727
pubmed: 31776419
Br J Cancer. 1996 Jul;74(1):123-7
pubmed: 8679445
Int J Oncol. 2016 May;48(5):1825-36
pubmed: 26984042
Oncol Lett. 2016 Aug;12(2):1373-1379
pubmed: 27446440
Int J Med Sci. 2019 Jun 10;16(7):981-989
pubmed: 31341411
Oncotarget. 2017 Jul 8;9(37):24653-24671
pubmed: 29872495
Eur J Pharmacol. 2020 Aug 5;880:173126
pubmed: 32348778
Invest New Drugs. 2017 Jun;35(3):324-333
pubmed: 28150073
Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12964
pubmed: 29873837
Mol Med Rep. 2019 Apr;19(4):2707-2715
pubmed: 30720096
Adv Exp Med Biol. 2011;704:435-49
pubmed: 21290310
Acta Pharmacol Sin. 2018 Nov;39(11):1699-1705
pubmed: 29921886
Nat Immunol. 2009 Jan;10(1):21-7
pubmed: 19088738
Int J Oncol. 2018 Oct;53(4):1763-1773
pubmed: 30066890
World J Gastroenterol. 2014 Aug 21;20(31):10813-24
pubmed: 25152584
Int J Mol Sci. 2016 Jan 12;17(1):
pubmed: 26771606
Nat Rev Cancer. 2010 Jan;10(1):9-22
pubmed: 20029421
Front Pharmacol. 2020 Nov 30;11:587664
pubmed: 33390961
Cancers (Basel). 2020 Apr 06;12(4):
pubmed: 32268494
Asian Pac J Cancer Prev. 2014;15(10):4271-4
pubmed: 24935383
Biol Res. 2017 Oct 2;50(1):33
pubmed: 28969709
Scientifica (Cairo). 2012;2012:415158
pubmed: 24278689
Nat Struct Mol Biol. 2018 Jan;25(1):4-12
pubmed: 29323277
Nat Commun. 2014 Dec 04;5:5690
pubmed: 25471132
Mol Cell. 2017 Jun 15;66(6):780-788
pubmed: 28622523
Int J Mol Sci. 2019 Nov 11;20(22):
pubmed: 31718020
Front Med (Lausanne). 2017 Dec 08;4:227
pubmed: 29276709
PLoS Biol. 2019 Nov 25;17(11):e3000434
pubmed: 31765370
Elife. 2019 Nov 11;8:
pubmed: 31710287
Biochem Pharmacol. 2013 May 15;85(10):1417-23
pubmed: 23500550
Acta Pharm Sin B. 2017 Jan;7(1):3-17
pubmed: 28119804
Curr Opin Cell Biol. 2014 Apr;27:126-35
pubmed: 24508914
Biomolecules. 2020 Oct 15;10(10):
pubmed: 33076386
Curr Oncol. 2019 Apr;26(2):e121-e127
pubmed: 31043817
Mol Oncol. 2017 Jul;11(7):824-846
pubmed: 28614624
Oncotarget. 2017 Jul 25;8(30):50252-50272
pubmed: 28477017
Transl Oncol. 2017 Dec;10(6):956-975
pubmed: 29078205
Nature. 2006 Sep 14;443(7108):230-3
pubmed: 16921383
Science. 2010 Oct 1;330(6000):43-4
pubmed: 20929798