Antimicrobial Peptides: A Potent Alternative to Antibiotics.
ESKAPE
antibiotic resistance
antimicrobial peptides
multidrug resistance
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
10 Sep 2021
10 Sep 2021
Historique:
received:
18
08
2021
revised:
02
09
2021
accepted:
06
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been described. This review focuses on their use against ESKAPE bacteria, especially in biofilm treatments, their synergistic activity, and their application as prophylactic agents. Limitations and challenges restricting therapeutic applications are highlighted, and solutions for each challenge are evaluated to analyze whether antimicrobial peptides could replace antibiotics in the near future.
Identifiants
pubmed: 34572678
pii: antibiotics10091095
doi: 10.3390/antibiotics10091095
pmc: PMC8466391
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Assistance Publique - Hôpitaux de Paris
ID : CHU Bicêtre
Organisme : Université Paris-Saclay
ID : Eq Resist
Organisme : Institut National de la Santé et de la Recherche Médicale
ID : U1184
Organisme : Agence Nationale de la Recherche
ID : ANR-10-LABX-33
Organisme : Agence Nationale de la Recherche
ID : ANR-19-AMRB-0004
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