Perioperative Systemic Chemotherapy for Colorectal Liver Metastasis: Recent Updates.
adjuvant chemotherapy
colorectal neoplasms
liver
metastasis
neoadjuvant therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
13 Sep 2021
13 Sep 2021
Historique:
received:
19
08
2021
accepted:
10
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
The liver is the most common site of metastases for colorectal cancer. Complete resection in some patients with resectable liver metastases (LM) can lead to long-term survival and cure. Adjuvant systemic chemotherapy after complete resection of LM improves recurrence-free survival; however, the overall survival benefit is not clear. In selected patients, preoperative systemic treatment for metastatic colorectal cancer can convert unresectable to resectable cancer. This review will focus on patient selection, and integration of perioperative and postoperative systemic treatment to surgery in resectable and initially unresectable LM. Additionally, new drugs and biomarkers will be discussed.
Identifiants
pubmed: 34572817
pii: cancers13184590
doi: 10.3390/cancers13184590
pmc: PMC8464667
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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