The Psychoneuroimmunology of Stress Regulation in Pediatric Cancer Patients.
allostasis
childhood cancer
cytotoxic cancer treatment
early life stress
interventions
stress
stress dysregulation
stress reactivity
stress regulatory pathways
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
18 Sep 2021
18 Sep 2021
Historique:
received:
30
07
2021
revised:
16
09
2021
accepted:
17
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Stress is a ubiquitous experience that can be adaptive or maladaptive. Physiological stress regulation, or allostasis, can be disrupted at any point along the regulatory pathway resulting in adverse effects for the individual. Children with cancer exhibit significant changes to these pathways in line with stress dysregulation and long-term effects similar to those observed in other early-life stress populations, which are thought to be, in part, a result of cytotoxic cancer treatments. Children with cancer may have disruption to several steps in the stress-regulatory pathway including cognitive-affective function, neurological disruption to stress regulatory brain regions, altered adrenal and endocrine function, and disrupted tissue integrity, as well as lower engagement in positive coping behaviours such as physical activity and pro-social habits. To date, there has been minimal study of stress reactivity patterns in childhood illness populations. Nor has the role of stress regulation in long-term health and function been elucidated. We conclude that consideration of stress regulation in childhood cancer may be crucial in understanding and treating the disease.
Identifiants
pubmed: 34572911
pii: cancers13184684
doi: 10.3390/cancers13184684
pmc: PMC8468382
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Hospital for Sick Children
ID : Exercise Medicine Fund
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