Comparative Transcriptome Analysis of the Expression of Antioxidant and Immunity Genes in the Spleen of a Cyanidin 3-O-Glucoside-Treated Alzheimer's Mouse Model.
Alzheimer’s disease
antioxidant
cyanidin 3-O-glucoside
genes
immune modulation
mechanisms
transcriptome
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
09 Sep 2021
09 Sep 2021
Historique:
received:
20
07
2021
revised:
06
09
2021
accepted:
07
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Cyanidin 3-O-glucoside (C3G) is a well-known antioxidant found as a dietary anthocyanin in different fruits and vegetables. It has protective and therapeutic effects on various diseases. It can reduce neuronal death from amyloid-beta (Aβ)-induced toxicity and promote the inhibition of Aβ fibrillization. Antioxidant and immune modulation might play a critical role in the properties of C3G against Alzheimer's disease (AD) and other diseases. However, limited studies have been performed on the mechanism involved in the effect of C3G through transcriptome analysis. Thus, the objective of this study was to perform comparative transcriptome analysis of the spleen to determine gene expression profiles of wild-type mice (C57BL/6J Jms), an Alzheimer's mouse model (APPswe/PS1dE9 mice), and a C3G-treated Alzheimer's mouse model. Differentially expressed antioxidant, immune-related, and AD pathways genes were identified in the treated group. The validation of gene expression data via RT-PCR studies further supported the current findings. Six important antioxidant genes (S100a8, S100a9, Prdx2, Hp, Mpst, and Prxl2a) and a high number of immune-related genes were found to be upregulated in the treatment groups, suggesting the possible antioxidant and immunomodulatory mechanisms of C3G, respectively. Further studies are strongly recommended to elucidate the precise role of these essential genes and optimize the therapeutic function of C3G in AD and other disease conditions.
Identifiants
pubmed: 34573067
pii: antiox10091435
doi: 10.3390/antiox10091435
pmc: PMC8472539
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Cooperative Research Program of the Center for Companion Animal Research (Project No. PJ01476703)" by the Rural Development Administration, Republic of Korea
ID : Project No. PJ01476703
Organisme : "GRRC program of Gyeonggi province (GRRC-Gachon2020 (B03))", Development of Healthcare Contents based on AI.
ID : GRRC-Gachon2020 (B03)
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