High Numbers of CD163-Positive Macrophages in the Fibrotic Region of Exuberant Granulation Tissue in Horses.
CD163
MAC387
anti-inflammatory macrophages
exuberant granulation tissue (EGT)
horse wound healing
pro-inflammatory macrophages
proud flesh
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
18 Sep 2021
18 Sep 2021
Historique:
received:
21
06
2021
revised:
31
07
2021
accepted:
15
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Exuberant granulation tissue (EGT) is a frequently encountered complication during second intention healing in equine distal limb wounds. Although it is still unknown what exactly triggers the formation of this tissue, previous research has revealed a persistent inflammatory response in these wounds. In this preliminary study we examined this inflammatory response in EGT-developing wounds as well as in experimental induced wounds. Immunohistological stainings were performed to detect primary inflammatory immune cells (MAC387 staining) as well as pro-resolution immune cells (CD163 staining). Our results show a significantly higher amount of MAC387+ and CD163+ cells in the fibrotic regions of EGT compared with the 19-day-old experimental wounds. This persistent high amount of fibrosis-promoting CD163+ cells in EGT suggests that the wound healing processes in EGT-developing wounds are arrested at the level of the proliferation phase.
Identifiants
pubmed: 34573694
pii: ani11092728
doi: 10.3390/ani11092728
pmc: PMC8464979
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 1S22820N
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 1508419N
Organisme : Bijzonder Onderzoeksfonds UGent
ID : 01N02818
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