Breast Cancer Heterogeneity.
breast cancer
inter-tumor heterogeneity
intra-tumor heterogeneity
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
27 Aug 2021
27 Aug 2021
Historique:
received:
20
07
2021
revised:
22
08
2021
accepted:
26
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Breast tumor heterogeneity is a major challenge in the clinical management of breast cancer patients. Both inter-tumor and intra-tumor heterogeneity imply that each breast cancer (BC) could have different prognosis and would benefit from specific therapy. Breast cancer is a dynamic entity, changing during tumor progression and metastatization and this poses fundamental issues to the feasibility of a personalized medicine approach. The most effective therapeutic strategy for patients with recurrent disease should be assessed evaluating biopsies obtained from metastatic sites. Furthermore, the tumor progression and the treatment response should be strictly followed and radiogenomics and liquid biopsy might be valuable tools to assess BC heterogeneity in a non-invasive way.
Identifiants
pubmed: 34573897
pii: diagnostics11091555
doi: 10.3390/diagnostics11091555
pmc: PMC8468623
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministero della Salute
ID : Ricerca corrente and 5x1000 funds
Références
J Clin Pathol. 2011 Sep;64(9):822-8
pubmed: 21676924
Am J Clin Pathol. 2008 Dec;130(6):879-82
pubmed: 19019763
Cancers (Basel). 2019 Nov 28;11(12):
pubmed: 31795152
Mod Pathol. 2012 Jul;25(7):938-48
pubmed: 22388760
Histopathology. 2020 Jul;77(1):79-91
pubmed: 32281132
Am J Pathol. 2012 Nov;181(5):1807-22
pubmed: 23062488
Breast Cancer Res. 2020 Oct 15;22(1):107
pubmed: 33059724
Nat Rev Clin Oncol. 2015 Oct;12(10):573-83
pubmed: 26122181
Ann Oncol. 2015 Feb;26(2):259-71
pubmed: 25214542
Mod Pathol. 2011 Oct;24(10):1285-94
pubmed: 21926958
Eur Radiol. 2019 Aug;29(8):4456-4467
pubmed: 30617495
Ther Adv Med Oncol. 2014 May;6(3):88-100
pubmed: 24790649
Cancer Chemother Pharmacol. 2020 Jan;85(1):105-111
pubmed: 31754747
Clin Cancer Res. 2021 Jan 15;27(2):504-512
pubmed: 33082214
Lancet. 2017 Jun 17;389(10087):2430-2442
pubmed: 27939063
Nat Rev Genet. 2012 Nov;13(11):795-806
pubmed: 23044827
Cancer Discov. 2021 Jun 28;:
pubmed: 34183353
J Clin Oncol. 2014 Sep 20;32(27):2959-66
pubmed: 25071121
Ann Oncol. 2020 May;31(5):590-598
pubmed: 32245699
Cell. 2016 Sep 22;167(1):260-274.e22
pubmed: 27641504
Cell. 2012 May 25;149(5):979-93
pubmed: 22608084
Breast. 2017 Aug;34 Suppl 1:S36-S42
pubmed: 28666921
J Clin Oncol. 2016 Jul 20;34(21):2460-7
pubmed: 27138582
Nat Rev Clin Oncol. 2013 Aug;10(8):472-84
pubmed: 23836314
Endocr Relat Cancer. 2019 May;26(5):471-482
pubmed: 30844755
Ann Oncol. 2013 Jan;24(1):47-53
pubmed: 22847811
Sci Rep. 2016 Apr 07;6:24146
pubmed: 27052161
Science. 2013 Mar 29;339(6127):1546-58
pubmed: 23539594
J Natl Cancer Inst. 2018 Jun 1;110(6):568-580
pubmed: 29315431
Eur J Cancer. 1980 Mar;16(3):323-31
pubmed: 7371687
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Lancet. 2005 May 14-20;365(9472):1687-717
pubmed: 15894097
Cancers (Basel). 2021 Mar 30;13(7):
pubmed: 33808271
Int J Cancer. 1995 Dec 11;63(6):790-3
pubmed: 8847135
Breast Cancer Res. 2011 Feb 01;13(1):104
pubmed: 21345264
Nat Med. 2015 Nov;21(11):1318-25
pubmed: 26479923
Sci Transl Med. 2015 Nov 11;7(313):313ra182
pubmed: 26560360
Biochem Pharmacol. 2021 Jun;188:114589
pubmed: 33932470
Nat Commun. 2021 Mar 31;12(1):1998
pubmed: 33790302
PLoS One. 2016 Apr 13;11(4):e0152500
pubmed: 27073890
JNCI Cancer Spectr. 2018 Dec 13;2(4):pky056
pubmed: 31360876
Cancer Treat Rev. 2021 Sep;99:102257
pubmed: 34237488
Oncol Lett. 2019 Jul;18(1):449-455
pubmed: 31289516
J Pathol. 2012 May;227(1):42-52
pubmed: 22252965
Diagnostics (Basel). 2020 Sep 17;10(9):
pubmed: 32957579
J Clin Oncol. 2002 Feb 1;20(3):719-26
pubmed: 11821453
Clin Chim Acta. 1988 Jun 30;175(1):89-96
pubmed: 3168286
Med Oncol. 2011 Mar;28(1):57-63
pubmed: 20099049
Nat Rev Clin Oncol. 2018 Feb;15(2):81-94
pubmed: 29115304
Med Oncol. 2014 Oct;31(10):214
pubmed: 25216864
Lab Invest. 2015 Apr;95(4):377-84
pubmed: 25599534
Oncotarget. 2017 Jun 28;8(37):62029-62038
pubmed: 28977923
Lancet Oncol. 2012 Apr;13(4):e178-85
pubmed: 22469128
Nat Commun. 2020 Oct 9;11(1):5120
pubmed: 33037194
Cancer Discov. 2021 May 3;:
pubmed: 33941592
Eur J Cancer. 2014 Jan;50(2):277-89
pubmed: 24269135
Nat Commun. 2020 Sep 25;11(1):4861
pubmed: 32978398
Cell. 2018 Jan 11;172(1-2):373-386.e10
pubmed: 29224780
Nat Commun. 2014 Jun 03;5:4006
pubmed: 24892406
Ann Oncol. 2021 Aug;32(8):983-993
pubmed: 34272041
Nat Med. 2015 Jul;21(7):751-9
pubmed: 26099045
Am J Pathol. 2011 Mar;178(3):1221-32
pubmed: 21356373
Cell. 2018 Sep 6;174(6):1373-1387.e19
pubmed: 30193111
Br J Cancer. 2010 Oct 12;103(8):1139-43
pubmed: 20877357
Clin Cancer Res. 2016 Nov 1;22(21):5362-5369
pubmed: 27185370
Breast Cancer Res Treat. 2017 Nov;166(2):447-457
pubmed: 28799059
Front Med (Lausanne). 2017 Dec 08;4:227
pubmed: 29276709
Nat Rev Cancer. 2020 Feb;20(2):89-106
pubmed: 31836838
Pathol Oncol Res. 2021 Apr 09;27:599894
pubmed: 34257555
Cancer Discov. 2014 Feb;4(2):232-45
pubmed: 24356096
Am J Clin Pathol. 2014 Dec;142(6):755-66
pubmed: 25389328
NPJ Breast Cancer. 2021 Apr 16;7(1):41
pubmed: 33863896
Ann Surg Oncol. 2021 Oct;28(11):5907-5917
pubmed: 33748896
Br J Cancer. 2004 Jun 14;90(12):2344-8
pubmed: 15150568
Oncogene. 2003 Oct 20;22(47):7316-39
pubmed: 14576841
Clin Cancer Res. 2020 Oct 1;26(19):5172-5177
pubmed: 32546646
BMC Cancer. 2018 Jan 2;18(1):4
pubmed: 29291717
J Clin Invest. 2021 Mar 15;131(6):
pubmed: 33529175
Nat Rev Cancer. 2012 Apr 19;12(5):323-34
pubmed: 22513401
J Cell Biol. 2012 Feb 20;196(4):395-406
pubmed: 22351925
Sci Transl Med. 2012 May 30;4(136):136ra68
pubmed: 22649089
Cancer Treat Rev. 2013 Nov;39(7):691-700
pubmed: 23683721
Cell. 2012 May 25;149(5):994-1007
pubmed: 22608083
Clin Cancer Res. 2019 Jul 1;25(13):3986-3995
pubmed: 30979740
Nat Rev Clin Oncol. 2017 Dec;14(12):749-762
pubmed: 28975929
Breast Cancer Res. 2007;9(1):R6
pubmed: 17239243