Antitumor and Antioxidant Activity of S-Methyl Methionine Sulfonium Chloride against Liver Cancer Induced in Wistar Albino Rats by Diethyl Nitrosamine and Carbon Tertrachloride.
S-methyl methionine sulfonium chloride
anti-inflammatory
anti-metastatic
antioxidant
antitumor
hepatocarcinoma
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
15 09 2021
15 09 2021
Historique:
received:
21
07
2021
revised:
05
09
2021
accepted:
10
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
30
10
2021
Statut:
epublish
Résumé
Liver disease, especially liver cancer, has become a threat facing the world. Now, antioxidant products are garnering great attention for the treatment and prevention of many diseases. S-Methyl methionine sulfonium chloride (MMSC) is a methionine derivative and is present in many vegetables and has anti-inflammatory effects and antioxidants. This is the first study aiming to investigate the antitumor activity of the MMSC. This study was carried out on 60 male Wistar albino rats (4-6 weeks old age) and divided into four groups, with the first group as normal control, second group as hepatocarcinoma induced by diethyl nitrosamine and carbon tetrachloride (DEN/CCL4) group, third group as normal rats treated with MMSC, and fourth group as hepatocellular carcinoma (HCC) induced rats treated with MMSC. Our findings revealed that MMSC administration after HCC induction significantly improved (
Identifiants
pubmed: 34574650
pii: ijerph18189726
doi: 10.3390/ijerph18189726
pmc: PMC8466341
pii:
doi:
Substances chimiques
Antioxidants
0
Chlorides
0
Vitamin U
3485Y39925
Diethylnitrosamine
3IQ78TTX1A
Carbon
7440-44-0
Methionine
AE28F7PNPL
methionine methyl ester
BN630929UL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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