Breast Cancer and p16: Role in Proliferation, Malignant Transformation and Progression.
breast cancer
cellular senescence
immunohistochemistry
molecular subtype
p16 (INK4A) protein
Journal
Healthcare (Basel, Switzerland)
ISSN: 2227-9032
Titre abrégé: Healthcare (Basel)
Pays: Switzerland
ID NLM: 101666525
Informations de publication
Date de publication:
21 Sep 2021
21 Sep 2021
Historique:
received:
26
05
2021
revised:
04
09
2021
accepted:
06
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
The definition of new molecular biomarkers could provide a more reliable approach in predicting the prognosis of invasive breast cancers (IBC). The aim of this study is to analyze the expression of p16 protein in IBC, as well as its participation in malignant transformation. The study included 147 patients diagnosed with IBC. The presence of non-invasive lesions (NIL) was noted in each IBC and surrounding tissue. p16 expression was determined by reading the percentage of nuclear and/or cytoplasmic expression in epithelial cells of IBC and NIL, but also in stromal fibroblasts. Results showed that expression of p16 increases with the progression of cytological changes in the epithelium; it is significantly higher in IBC compared to NIL (
Identifiants
pubmed: 34575014
pii: healthcare9091240
doi: 10.3390/healthcare9091240
pmc: PMC8468846
pii:
doi:
Types de publication
Journal Article
Langues
eng
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