Structure, Activity and Function of the Protein Arginine Methyltransferase 6.
H3R2me2a
PRMT6
cancer
epigenetics
post-translational modification
protein arginine methylation
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
11 Sep 2021
11 Sep 2021
Historique:
received:
26
08
2021
revised:
07
09
2021
accepted:
08
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Members of the protein arginine methyltransferase (PRMT) family methylate the arginine residue(s) of several proteins and regulate a broad spectrum of cellular functions. Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that asymmetrically dimethylates the arginine residues of numerous substrate proteins. PRMT6 introduces asymmetric dimethylation modification in the histone 3 at arginine 2 (H3R2me2a) and facilitates epigenetic regulation of global gene expression. In addition to histones, PRMT6 methylates a wide range of cellular proteins and regulates their functions. Here, we discuss (i) the biochemical aspects of enzyme kinetics, (ii) the structural features of PRMT6 and (iii) the diverse functional outcomes of PRMT6 mediated arginine methylation. Finally, we highlight how dysregulation of PRMT6 is implicated in various types of cancers and response to viral infections.
Identifiants
pubmed: 34575100
pii: life11090951
doi: 10.3390/life11090951
pmc: PMC8470942
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Board of Research in Nuclear Sciences
ID : 37(1)/14/17/2017-BRNS/37019
Organisme : Indian Council of Medical Research
ID : Senior Research Fellowship
Organisme : Science and Engineering Research Board
ID : SRG/2019/001785
Organisme : Science and Engineering Research Board
ID : National Post-Doctoral Fellowship
Organisme : Department of Biotechnology, Ministry of Science and Technology, India
ID : BT/RLF/Re-entry/05/2018
Organisme : Ministry of Education: Prime Minister's Research Fellowship
ID : Research Fellowship
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