Risk Factors for Acute Kidney Injury Requiring Renal Replacement Therapy after Orthotopic Heart Transplantation in Patients with Preserved Renal Function.
calcineurin inhibitors
cardiac surgery
heart failure
prognosis
tacrolimus
vasopressors
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
12 Sep 2021
12 Sep 2021
Historique:
received:
24
08
2021
revised:
06
09
2021
accepted:
09
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Acute kidney injury (AKI), requiring renal replacement therapy (RRT). is a serious complication after orthotopic heart transplantation (HTX). In patients with preexisting impaired renal function, postoperative AKI is unsurprising. However, even in patients with preserved renal function, AKI requiring RRT is frequent. Therefore, this study aimed to identify risk factors associated with postoperative AKI requiring RRT after HTX in this sub-cohort. This retrospective cohort study included patients ≥ 18 years of age with preserved renal function (defined as preoperative glomerular filtration rate ≥ 60 mL/min) who underwent HTX between 2010 and 2021. In total, 107 patients were included in the analysis (mean age 52 ± 12 years, 78.5% male, 45.8% AKI requiring RRT). Based on univariate logistic regression, use of extracorporeal membrane oxygenation, postoperative infection, levosimendan therapy, duration of norepinephrine (NE) therapy and maximum daily increase in tacrolimus plasma levels were chosen to be included into multivariate analysis. Duration of NE therapy and maximum daily increase in tacrolimus plasma levels remained as independent significant risk factors (NE: OR 1.01, 95%CI: 1.00-1.02,
Identifiants
pubmed: 34575227
pii: jcm10184117
doi: 10.3390/jcm10184117
pmc: PMC8470552
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Sci Rep. 2017 Jan 30;7:41555
pubmed: 28134286
Pediatr Nephrol. 2018 Jul;33(7):1235-1242
pubmed: 29508077
Artif Organs. 2016 Aug;40(8):746-54
pubmed: 27139839
Braz J Cardiovasc Surg. 2018 Sep-Oct;33(5):454-461
pubmed: 30517253
Transplantation. 2018 Nov;102(11):1901-1908
pubmed: 29979343
Transpl Int. 2009 Jan;22(1):78-89
pubmed: 18954366
Crit Care. 2021 Jun 12;25(1):207
pubmed: 34118980
J Clin Epidemiol. 1995 Dec;48(12):1503-10
pubmed: 8543964
Cardiorenal Med. 2015 Dec;6(1):50-60
pubmed: 27194996
J Thorac Cardiovasc Surg. 2021 Apr;161(4):1346-1355.e3
pubmed: 32007252
J Cardiothorac Vasc Anesth. 2018 Oct;32(5):2152-2159
pubmed: 29580796
Clin J Am Soc Nephrol. 2009 Feb;4(2):481-508
pubmed: 19218475
Exp Clin Transplant. 2015 Nov;13 Suppl 3:26-9
pubmed: 26640905
Eur J Drug Metab Pharmacokinet. 2018 Jun;43(3):311-320
pubmed: 29236211
Crit Care. 2019 Jun 14;23(Suppl 1):149
pubmed: 31200777
BMC Nephrol. 2017 Jul 19;18(1):244
pubmed: 28724404
PLoS One. 2020 Aug 18;15(8):e0237503
pubmed: 32810154
J Clin Med. 2021 Mar 03;10(5):
pubmed: 33802296
Ann Card Anaesth. 2018 Jan-Mar;21(1):41-45
pubmed: 29336390
World J Transplant. 2016 Mar 24;6(1):144-54
pubmed: 27011912
ASAIO J. 2009 Jul-Aug;55(4):412-6
pubmed: 19381083
Eur J Cardiothorac Surg. 2011 Dec;40(6):1355-61; discussion 1361
pubmed: 21514175
Clin Pharmacol Ther. 2020 Feb;107(2):462-470
pubmed: 31513279
Clin Transplant. 2010 Nov-Dec;24(6):E207-13
pubmed: 20184627
J Cardiothorac Vasc Anesth. 2021 Oct;35(10):3067-3077
pubmed: 33069558
Eur J Cardiothorac Surg. 2010 Feb;37(2):334-8
pubmed: 19692267
Heart Surg Forum. 2021 Mar 25;24(2):E282-E292
pubmed: 33798050
Ann Intern Med. 2009 May 5;150(9):604-12
pubmed: 19414839
J Clin Med. 2020 Jul 31;9(8):
pubmed: 32751950
Medicines (Basel). 2019 Nov 01;6(4):
pubmed: 31683875
Transplant Proc. 2016 Jan-Feb;48(1):167-72
pubmed: 26915863
Clin Transplant. 2021 Jun;35(6):e14296
pubmed: 33759249
Lancet. 2012 Aug 25;380(9843):756-66
pubmed: 22617274
Transplant Proc. 2017 Nov;49(9):2065-2069
pubmed: 29149962