Ambulatory COVID-19 Patients Treated with Lactoferrin as a Supplementary Antiviral Agent: A Preliminary Study.
COVID-19 patients
SARS-CoV-2
lactoferrin
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
21 Sep 2021
21 Sep 2021
Historique:
received:
27
07
2021
revised:
08
09
2021
accepted:
17
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
SARS-CoV-2, an enveloped, single-stranded RNA virus causing COVID-19, exerts morbidity and mortality especially in elderly, obese individuals and those suffering from chronic conditions. In addition to the availability of vaccines and the limited efficacy of the first dose of vaccine against SARS-CoV-2 variants, there is an urgent requirement for the discovery and development of supplementary antiviral agents. Lactoferrin (Lf), a pleiotropic cationic glycoprotein of innate immunity, has been proposed as a safe treatment combined with other therapies in COVID-19 patients. Here, we present a small retrospective study on asymptomatic, paucisymptomatic, and moderate symptomatic COVID-19 Lf-treated versus Lf-untreated patients. The time required to achieve SARS-CoV-2 RNA negativization in Lf-treated patients (
Identifiants
pubmed: 34575388
pii: jcm10184276
doi: 10.3390/jcm10184276
pmc: PMC8469309
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Front Immunol. 2018 Sep 21;9:2123
pubmed: 30298070
Eur Arch Psychiatry Clin Neurosci. 2021 Mar 12;:
pubmed: 33710424
Molecules. 2019 Apr 03;24(7):
pubmed: 30987256
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
Front Biosci (Landmark Ed). 2020 Jan 1;25:893-911
pubmed: 31585922
Front Mol Biosci. 2021 Feb 15;8:607443
pubmed: 33659275
J Clin Virol. 2020 Jun;127:104370
pubmed: 32344321
J Infect Chemother. 2014 Nov;20(11):666-71
pubmed: 25182867
Int J Mol Sci. 2017 Sep 15;18(9):
pubmed: 28914813
Science. 2005 Sep 16;309(5742):1864-8
pubmed: 16166518
Cell Mol Life Sci. 2005 Nov;62(22):2576-87
pubmed: 16261253
Front Med. 2020 Apr;14(2):185-192
pubmed: 32170560
Sci Rep. 2021 Jan 15;11(1):1580
pubmed: 33452298
Viruses. 2019 Jul 01;11(7):
pubmed: 31266258
Int J Mol Sci. 2019 Apr 30;20(9):
pubmed: 31052156
Biometals. 2014 Oct;27(5):999-1006
pubmed: 24590680
ACS Chem Neurosci. 2020 May 6;11(9):1200-1203
pubmed: 32283006
Am J Hematol. 2021 Jan;96(1):E32-E35
pubmed: 33075189
Comp Biochem Physiol B. 1984;78(3):575-80
pubmed: 6434227
Cell Discov. 2020 Nov 4;6(1):80
pubmed: 33298900
Mol Imaging Radionucl Ther. 2013 Dec;22(3):73-5
pubmed: 24416621
Biochim Biophys Acta. 2011 May;1813(5):878-88
pubmed: 21296109
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
Front Immunol. 2017 Nov 06;8:1438
pubmed: 29163511
J Dairy Sci. 2013 Apr;96(4):2061-2070
pubmed: 23375971
Nutrients. 2021 Jan 23;13(2):
pubmed: 33498631
Nature. 2003 Nov 27;426(6965):450-4
pubmed: 14647384
PLoS One. 2011;6(8):e23710
pubmed: 21887302
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Science. 2020 May 1;368(6490):473-474
pubmed: 32303591
Cell. 2020 Nov 12;183(4):1043-1057.e15
pubmed: 32970989
Emerg Microbes Infect. 2020 Dec;9(1):1123-1130
pubmed: 32475230
Front Immunol. 2018 Mar 01;9:376
pubmed: 29545798
Respir Physiol Neurobiol. 2021 Jan;283:103548
pubmed: 32956843
Elife. 2020 Nov 09;9:
pubmed: 33164751
Cell Mol Life Sci. 2005 Nov;62(22):2549-59
pubmed: 16261255
Front Pharmacol. 2021 Jun 17;12:666600
pubmed: 34220505
Biometals. 2020 Jun;33(2-3):159-168
pubmed: 32274616
Front Immunol. 2017 Jun 15;8:705
pubmed: 28663751
Molecules. 2020 Apr 24;25(8):
pubmed: 32344579
Annu Rev Nutr. 1995;15:93-110
pubmed: 8527233
Brain Behav Immun. 2016 Aug;56:10-1
pubmed: 27223097
Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620938149
pubmed: 32677459
CJEM. 2020 Sep;22(5):595-602
pubmed: 32507123
Int J Antimicrob Agents. 2020 Sep;56(3):106118
pubmed: 32738305
J Biol Chem. 2018 Jun 1;293(22):8600-8613
pubmed: 29669808
Emerg Microbes Infect. 2021 Dec;10(1):317-330
pubmed: 33560940
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Int J Oral Sci. 2020 Feb 24;12(1):8
pubmed: 32094336
Molecules. 2011 Aug 16;16(8):6992-7018
pubmed: 21847071
Nature. 2020 May;581(7807):215-220
pubmed: 32225176
Cell. 2020 May 14;181(4):894-904.e9
pubmed: 32275855
Int J Mol Sci. 2020 Jul 11;21(14):
pubmed: 32664543
Exp Gerontol. 2018 May;105:10-18
pubmed: 29275161