Bleomycin Concentration in Patients' Plasma and Tumors after Electrochemotherapy. A Study from InspECT Group.
bleomycin
blood samples
drug delivery
electrochemotherapy
electroporation
pharmacokinetics
tumor samples
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
24 Aug 2021
24 Aug 2021
Historique:
received:
16
07
2021
revised:
14
08
2021
accepted:
19
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
The plasma concentration profile of bleomycin in the distribution phase of patients younger than 65 years is needed to determine the suitable time interval for efficient application of electric pulses during electrochemotherapy. Additionally, bleomycin concentrations in the treated tumors for effective tumor response are not known. In this study, the pharmacokinetic profile of bleomycin in the distribution phase in 12 patients younger than 65 years was determined. In 17 patients, the intratumoral bleomycin concentration was determined before the application of electric pulses. In younger patients, the pharmacokinetics of intravenously injected bleomycin demonstrated a faster plasma clearance rate than that in patients older than 65 years. This outcome might indicate that the lowering of the standard bleomycin dose of 15,000 IU/m
Identifiants
pubmed: 34575400
pii: pharmaceutics13091324
doi: 10.3390/pharmaceutics13091324
pmc: PMC8469090
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : P3-0003
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : P1-0143
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : P3-0067
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : P3-0307
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : J3-9269
Références
Radiol Oncol. 2020 Feb 19;54(1):79-85
pubmed: 32074076
J Control Release. 2021 Apr 10;332:623-635
pubmed: 33705828
Melanoma Res. 2005 Feb;15(1):45-51
pubmed: 15714120
Eur J Cancer. 2020 Oct;138:30-40
pubmed: 32836172
Bioelectrochemistry. 2021 Aug;140:107832
pubmed: 33984694
Head Neck. 2018 Jan;40(1):120-125
pubmed: 29130624
Radiol Oncol. 2016 Jul 19;50(3):274-9
pubmed: 27679543
Talanta. 2016 Nov 1;160:164-171
pubmed: 27591601
Anticancer Drugs. 1996 Sep;7(7):785-91
pubmed: 8949991
Cancers (Basel). 2020 Dec 15;12(12):
pubmed: 33333941
Basic Clin Pharmacol Toxicol. 2018 Sep;123(3):247-256
pubmed: 29573558
Eur J Surg Oncol. 2020 Sep;46(9):1628-1633
pubmed: 32387070
Semin Oncol. 2019 Apr;46(2):173-191
pubmed: 31122761
J Eur Acad Dermatol Venereol. 2018 Jul;32(7):1147-1154
pubmed: 29178483
Eur J Surg Oncol. 2021 Aug;47(8):1836-1846
pubmed: 33726951
Eur J Cancer. 2016 Aug;63:41-52
pubmed: 27267144
Jpn J Cancer Res. 1998 Mar;89(3):328-33
pubmed: 9600128
Eur J Cancer. 2009 Jan;45(2):228-47
pubmed: 19097774
Br J Oral Maxillofac Surg. 2014 Dec;52(10):957-64
pubmed: 25183266
Cancer Chemother Pharmacol. 2016 May;77(5):939-47
pubmed: 26992379
Radiol Oncol. 2012 Dec;46(4):302-11
pubmed: 23412658
Cancer Chemother Pharmacol. 1982;9(1):22-5
pubmed: 6183016
Acta Oncol. 2018 Jul;57(7):874-882
pubmed: 29577784
Sci Rep. 2020 Jan 31;10(1):1563
pubmed: 32005919
Eur J Surg Oncol. 2013 Jan;39(1):4-16
pubmed: 22980492
Clin Breast Cancer. 2018 Oct;18(5):e909-e917
pubmed: 29673795
Anal Chim Acta. 2021 Jun 1;1162:338424
pubmed: 33926700
Cancer Chemother Pharmacol. 1979;3(1):33-40
pubmed: 93987