Ultrasound-Responsive Smart Drug Delivery System of Lipid Coated Mesoporous Silica Nanoparticles.
cellular uptake
lipid coating
mechanical index
mesoporous silica nanoparticles
ultrasound triggered release
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
03 Sep 2021
03 Sep 2021
Historique:
received:
09
08
2021
revised:
27
08
2021
accepted:
31
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
The immediate release of chemotherapeutics at the target site, along with no premature release in circulation is always challenging. The purpose of this study was to develop a stimuli responsive drug delivery system, composed of lipid supported mesoporous silica nanoparticles (MSNPs) for triggered drug release at the target site and simultaneously avoiding the premature release. MSNPs with a higher drug loading capacity and very slow release were designed so as to enhance release by FDA approved US-irradiation. Doxorubicin, as a model drug, and perfluoropentane (PFP) as a US responsive material, were entrapped in the porous structure of MSNPs. Lipid coating enhanced the cellular uptake and in addition provided a gatekeeping effect at the pore opening to reduce premature release. The mechanical and thermal effects of US induced the conversion of liquid PFP to a gaseous form that was able to rupture the lipid layer, resulting in triggered drug release. The prolonged stability profile and non-toxic behavior made them suitable candidate for the delivery of anticancer drugs. This smart system, with the abilities of better cellular uptake and higher cytotoxic effects on US-irradiation, would be a good addition to the applied side of chemotherapeutic advanced drug delivery systems.
Identifiants
pubmed: 34575472
pii: pharmaceutics13091396
doi: 10.3390/pharmaceutics13091396
pmc: PMC8468042
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Am Chem Soc. 2019 Nov 6;141(44):17670-17684
pubmed: 31604010
Ultrasound Med Biol. 2002 Mar;28(3):339-48
pubmed: 11978414
J Acoust Soc Am. 2012 Jan;131(1):540-9
pubmed: 22280615
Colloids Surf B Biointerfaces. 2018 Dec 1;172:728-733
pubmed: 30245298
J Control Release. 2011 Jan 5;149(1):36-41
pubmed: 20470839
Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:1267-1280
pubmed: 27987683
Nano Lett. 2010 Jul 14;10(7):2484-92
pubmed: 20515041
ACS Nano. 2015 Nov 24;9(11):11023-33
pubmed: 26456489
Chem Mater. 2016 Aug 23;28(16):5962-5972
pubmed: 28484307
J Control Release. 2010 Nov 20;148(1):13-17
pubmed: 20691227
Expert Opin Drug Deliv. 2019 Oct;16(10):1095-1112
pubmed: 31469003
Eur J Pharm Biopharm. 2021 Aug;165:31-40
pubmed: 33962002
Adv Drug Deliv Rev. 2014 Jun;72:3-14
pubmed: 24389162
ACS Nano. 2016 Mar 22;10(3):2991-4
pubmed: 26881288
J Control Release. 2013 Jun 10;168(2):209-24
pubmed: 23517784
Drug Deliv. 2017 Nov;24(1):681-691
pubmed: 28414557
Drug Deliv. 2018 Nov;25(1):1526-1536
pubmed: 29996694
ACS Appl Mater Interfaces. 2013 Nov 13;5(21):10895-903
pubmed: 24127854
Chem Rev. 2015 Oct 14;115(19):10938-66
pubmed: 26010257
Expert Opin Drug Deliv. 2017 Jun;14(6):783-796
pubmed: 27575454
Int J Hyperthermia. 2019;36(1):196-203
pubmed: 30541350
Int J Pharm. 2020 Feb 15;575:118961
pubmed: 31846731
Langmuir. 2019 Aug 6;35(31):10173-10191
pubmed: 30653325
Mater Sci Eng C Mater Biol Appl. 2020 Oct;115:111116
pubmed: 32600717
Pharmaceutics. 2021 Jul 26;13(8):
pubmed: 34452096
ChemMedChem. 2016 Feb 4;11(3):340-9
pubmed: 26662675
Adv Healthc Mater. 2017 Sep;6(18):
pubmed: 28699308
Nanotechnology. 2016 Jun 17;27(24):245101
pubmed: 27172065
Ultrason Sonochem. 2017 May;36:262-269
pubmed: 28069209
ACS Nano. 2016 Feb 23;10(2):2702-15
pubmed: 26835979
Anatol J Cardiol. 2015 Apr;15(4):334-6
pubmed: 25880292
Biomaterials. 2014 Apr;35(11):3650-65
pubmed: 24462359
ACS Appl Mater Interfaces. 2018 Sep 26;10(38):31870-31881
pubmed: 30160469
Eur J Pharm Biopharm. 2019 Feb;135:72-82
pubmed: 30590107
J Control Release. 2015 Jan 10;197:20-8
pubmed: 25449801
Int J Nanomedicine. 2021 Feb 11;16:951-976
pubmed: 33603362
ACS Nano. 2016 Sep 27;10(9):8325-45
pubmed: 27419663
Biomaterials. 2013 Oct;34(31):7662-73
pubmed: 23859657
Cell Cycle. 2015;14(18):2891-8
pubmed: 26178635
Drug Discov Today. 2018 May;23(5):1043-1052
pubmed: 29155366
Front Chem. 2019 Feb 11;7:59
pubmed: 30805332
ACS Nano. 2011 Jul 26;5(7):5647-55
pubmed: 21648482
J Control Release. 2019 Dec 28;316:79-92
pubmed: 31676384
Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14291-4
pubmed: 26439669
ACS Appl Mater Interfaces. 2014 Mar 12;6(5):3491-500
pubmed: 24471488
Eur J Pharm Biopharm. 2020 May;150:50-65
pubmed: 32151728
J Control Release. 2017 Nov 28;266:75-86
pubmed: 28928042
Nanoscale. 2019 Aug 29;11(34):15958-15970
pubmed: 31418432
Nanoscale. 2018 Mar 1;10(9):4258-4266
pubmed: 29436549
Int J Nanomedicine. 2016 Dec 20;12:87-110
pubmed: 28053526