Contribution of CYP2D6 Functional Activity to Oxycodone Efficacy in Pain Management: Genetic Polymorphisms, Phenoconversion, and Tissue-Selective Metabolism.
COMT
CYP2D6
OPRM1
efficacy
oxycodone
oxymorphone
pharmacogenetics
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
14 Sep 2021
14 Sep 2021
Historique:
received:
26
07
2021
revised:
26
08
2021
accepted:
03
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Oxycodone is a widely used opioid for the management of chronic pain. Analgesic effects observed following the administration of oxycodone are mediated mostly by agonistic effects on the μ-opioid receptor. Wide inter-subject variability observed in oxycodone efficacy could be explained by polymorphisms in the gene coding for the μ-opioid receptor (
Identifiants
pubmed: 34575542
pii: pharmaceutics13091466
doi: 10.3390/pharmaceutics13091466
pmc: PMC8468517
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Drug Metab Rev. 2009;41(4):573-643
pubmed: 19645588
Anesthesiology. 2006 Oct;105(4):801-12
pubmed: 17006080
Fundam Clin Pharmacol. 2015 Aug;29(4):417-25
pubmed: 26042474
Anesthesiology. 2007 May;106(5):1063-4; author reply 1064-5
pubmed: 17457147
Br J Clin Pharmacol. 2010 Jul;70(1):78-87
pubmed: 20642550
Pharmacogenetics. 1997 Oct;7(5):375-9
pubmed: 9352573
Eur J Clin Pharmacol. 2009 Mar;65(3):263-71
pubmed: 18836708
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:144-158
pubmed: 27978469
Drug Metab Pharmacokinet. 2003;18(6):337-49
pubmed: 15618754
Curr Drug Metab. 2010 Oct;11(8):659-66
pubmed: 20942780
J Pharm Biomed Anal. 2017 Sep 10;144:129-137
pubmed: 27692933
Prim Care Companion J Clin Psychiatry. 2006;8(3):122-30
pubmed: 16912814
PLoS One. 2018 May 24;13(5):e0197734
pubmed: 29795628
J Anal Toxicol. 2006 Oct;30(8):570-5
pubmed: 17132254
Drug Metab Dispos. 2004 Apr;32(4):447-54
pubmed: 15039299
Anesthesiology. 2008 Mar;108(3):495-505
pubmed: 18292687
Pharmacogenomics. 2009 Apr;10(4):669-84
pubmed: 19374521
Biol Res Nurs. 2017 Mar;19(2):170-179
pubmed: 27903758
Clin J Pain. 2019 Jan;35(1):77-86
pubmed: 30028366
Clin Pharmacol Ther. 2006 May;79(5):461-79
pubmed: 16678548
Yakugaku Zasshi. 2015;135(5):697-702
pubmed: 25948304
Br J Clin Pharmacol. 1992 Jun;33(6):617-21
pubmed: 1389934
Clin Pharmacol Ther. 2019 Dec;106(6):1280-1289
pubmed: 31099895
Biochem Biophys Res Commun. 1998 Aug 28;249(3):838-43
pubmed: 9731223
Life Sci. 1999;64(22):2011-20
pubmed: 10374926
Fundam Clin Pharmacol. 2010 Aug;24(4):517-24
pubmed: 19845769
Biol Pharm Bull. 2017 Sep 1;40(9):1344-1351
pubmed: 28626197
Pharmacogenet Genomics. 2009 Jun;19(6):429-36
pubmed: 19514130
J Clin Psychopharmacol. 2003 Aug;23(4):420-1
pubmed: 12920424
Eur J Clin Pharmacol. 2010 Apr;66(4):387-97
pubmed: 20076952
Xenobiotica. 1997 Jan;27(1):111-25
pubmed: 9041683
Clin Pharmacol Ther. 2021 Oct;110(4):888-896
pubmed: 33387367
Scand J Pain. 2017 Dec 29;1(1):24-33
pubmed: 29913934
Drug Metab Dispos. 2006 May;34(5):880-6
pubmed: 16467132
Front Pharmacol. 2012 Jan 05;2:87
pubmed: 22291644
Neuropharmacology. 2008 Dec;55(7):1147-55
pubmed: 18687346
Pain Physician. 2015 Mar-Apr;18(2):131-52
pubmed: 25794200
Br J Clin Pharmacol. 2014 Apr;77(4):673-83
pubmed: 24033670
Pharmaceutics. 2020 Sep 04;12(9):
pubmed: 32899642
J Pain. 2014 Dec;15(12):1248-56
pubmed: 25239082
Anesthesiology. 2009 Jun;110(6):1371-8
pubmed: 19417618
AAPS J. 2012 Mar;14(1):87-96
pubmed: 22215264
Drug Metab Dispos. 2009 Jul;37(7):1528-38
pubmed: 19359404
Br J Clin Pharmacol. 2002 Feb;53(2):111-22
pubmed: 11851634
J Anal Toxicol. 2002 Oct;26(7):438-47
pubmed: 12422998
J Pharmacol Exp Ther. 2004 Feb;308(2):547-54
pubmed: 14600248
Pharmgenomics Pers Med. 2019 Nov 27;12:361-368
pubmed: 31819591
Br J Pharmacol. 2010 Jun;160(4):907-18
pubmed: 20590587
Biochem Biophys Res Commun. 1987 Nov 13;148(3):1144-50
pubmed: 3500719
J Pharm Biomed Anal. 2019 Sep 5;173:96-107
pubmed: 31125949
J Pharmacol Exp Ther. 2008 Nov;327(2):538-45
pubmed: 18698000
Mol Pharmacol. 1997 Dec;52(6):1034-40
pubmed: 9415713
Mol Med Rep. 2019 Mar;19(3):1423-1434
pubmed: 30592275
Drugs R D. 2005;6(2):91-9
pubmed: 15777102
Clin Pharmacol Ther. 2019 Oct;106(4):831-840
pubmed: 31002385
Br J Pharmacol. 2010 Jun;160(4):919-30
pubmed: 20590588
Eur J Cancer. 2011 Jul;47(11):1682-91
pubmed: 21570824
Clin Toxicol (Phila). 2015 Jul;53(6):501-10
pubmed: 25998998
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Sep 30;30(7):1356-8
pubmed: 16631290
Life Sci. 1991;48(22):2165-71
pubmed: 1851921
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 1;1008:174-180
pubmed: 26655109
Expert Opin Drug Metab Toxicol. 2014 Nov;10(11):1569-83
pubmed: 25316321
Drug Metab Dispos. 2006 Sep;34(9):1624-31
pubmed: 16763013
Acta Anaesthesiol Scand. 2010 Feb;54(2):232-40
pubmed: 19719813
Pain. 2005 Jul;116(1-2):73-8
pubmed: 15927391
Eur J Pharmacol. 2010 Jan 25;626(2-3):171-8
pubmed: 19818757
J Clin Pharmacol. 2012 Feb;52(2):234-42
pubmed: 21383334
Pharmacol Res Perspect. 2020 Oct;8(5):e00645
pubmed: 32851819
Eur J Clin Pharmacol. 2011 Jan;67(1):63-71
pubmed: 20857093
Br J Pharmacol. 2021 Dec;178(23):4708-4725
pubmed: 34363609
Arch Pharm Res. 2018 Sep;41(9):921-930
pubmed: 30191460
Biochem Soc Trans. 1997 Nov;25(4):S577
pubmed: 9450005
Br J Pharmacol. 2008 Mar;153 Suppl 1:S82-9
pubmed: 18026129
Pain Pract. 2007 Dec;7(4):352-6
pubmed: 17986163
Drug Metab Dispos. 1998 Jan;26(1):73-7
pubmed: 9443856
Eur J Clin Pharmacol. 2011 Aug;67(8):859-61
pubmed: 21221960
J Clin Pharmacol. 2010 Jan;50(1):101-8
pubmed: 19755414
Eur J Clin Pharmacol. 2012 Jan;68(1):55-64
pubmed: 21735164
Am J Transl Res. 2018 Sep 15;10(9):2764-2780
pubmed: 30323865
Br J Clin Pharmacol. 1991 Oct;32(4):516-8
pubmed: 1958450
Pharmacogenetics. 2003 Mar;13(3):173-81
pubmed: 12618595
Anesthesiology. 2014 Oct;121(4):825-34
pubmed: 25102313
Drug Metab Dispos. 1983 Sep-Oct;11(5):446-50
pubmed: 6194952
Asian Pac J Cancer Prev. 2013;14(5):2937-43
pubmed: 23803057
Pharmacotherapy. 2004 Apr;24(4):468-76
pubmed: 15098800
Clin Drug Investig. 2011;31(3):143-53
pubmed: 21142269
Natl Health Stat Report. 2020 Jan;(135):1-12
pubmed: 32510308
Drug Metab Rev. 2004 May;36(2):243-77
pubmed: 15237854
Pharmacogenet Genomics. 2012 Sep;22(9):673-91
pubmed: 22722321
J Anal Toxicol. 2015 Oct;39(8):637-41
pubmed: 26378138
Cell Mol Life Sci. 2001 May;58(5-6):737-47
pubmed: 11437235
J Pharm Sci. 1979 Apr;68(4):527-8
pubmed: 35601
Basic Clin Pharmacol Toxicol. 2009 Apr;104(4):335-44
pubmed: 19281600
Clin Pharmacol Ther. 1998 Dec;64(6):603-11
pubmed: 9871425
Pharmacogenetics. 2001 Apr;11(3):237-45
pubmed: 11337939
J Psychiatry Neurosci. 2002 Nov;27(6):406-15
pubmed: 12491573
Front Pharmacol. 2018 Apr 05;9:305
pubmed: 29674966
PLoS One. 2013;8(3):e60239
pubmed: 23555934
Int J Mol Sci. 2021 May 07;22(9):
pubmed: 34067027
J Pers Med. 2021 Nov 10;11(11):
pubmed: 34834526
J Pharm Sci. 2013 Sep;102(9):3320-31
pubmed: 23463542
Basic Clin Pharmacol Toxicol. 2019 Mar;124(3):245-255
pubmed: 30253071
Br J Clin Pharmacol. 2019 Jun;85(6):1367-1377
pubmed: 30817016