mRNA-Based Nanomedicinal Products to Address Corneal Inflammation by Interleukin-10 Supplementation.
advanced therapies
corneal epithelium
corneal inflammation
gene augmentation
interleukin-10
messenger RNA
polyvinyl alcohol
solid lipid nanoparticles
topical administration
transfection
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
15 Sep 2021
15 Sep 2021
Historique:
received:
26
07
2021
revised:
27
08
2021
accepted:
11
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
The anti-inflammatory cytokine Interleukin-10 (IL-10) is considered an efficient treatment for corneal inflammation, in spite of its short half-life and poor eye bioavailability. In the present work, mRNA-based nanomedicinal products based on solid lipid nanoparticles (SLNs) were developed in order to produce IL-10 to treat corneal inflammation. mRNA encoding green fluorescent protein (GFP) or human IL-10 was complexed with different SLNs and ligands. After, physicochemical characterization, transfection efficacy, intracellular disposition, cellular uptake and IL-10 expression of the nanosystems were evaluated
Identifiants
pubmed: 34575548
pii: pharmaceutics13091472
doi: 10.3390/pharmaceutics13091472
pmc: PMC8466377
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Euskal Herriko Unibertsitatea
ID : GIU 20/048
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