Mesenchymal Stromal Cells: Potential Option for COVID-19 Treatment.
ARDS
COVID-19
MSCs
immunomodulation
mesenchymal stromal cells
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
16 Sep 2021
16 Sep 2021
Historique:
received:
30
06
2021
revised:
01
09
2021
accepted:
11
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
The COVID-19 pandemic has significantly impacted the way of life worldwide and continues to bring high mortality rates to at-risk groups. Patients who develop severe COVID-19 pneumonia, often complicated with ARDS, are left with limited treatment options with no targeted therapy currently available. One of the features of COVID-19 is an overaggressive immune reaction that leads to multiorgan failure. Mesenchymal stromal cell (MSC) treatment has been in development for various clinical indications for over a decade, with a safe side effect profile and promising results in preclinical and clinical trials. Therefore, the use of MSCs in COVID-19-induced respiratory failure and ARDS was a logical step in order to find a potential treatment option for the most severe patients. In this review, the main characteristics of MSCs, their proposed mechanism of action in COVID-19 treatment and the effect of this therapy in published case reports and clinical trials are discussed.
Identifiants
pubmed: 34575557
pii: pharmaceutics13091481
doi: 10.3390/pharmaceutics13091481
pmc: PMC8469913
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Nature. 2003 Nov 27;426(6965):450-4
pubmed: 14647384
Eur J Clin Microbiol Infect Dis. 2020 Jun;39(6):1011-1019
pubmed: 32291542
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Br J Haematol. 2003 Apr;121(2):368-74
pubmed: 12694261
J Infect Public Health. 2020 Nov;13(11):1652-1663
pubmed: 33008778
Front Physiol. 2021 Jan 28;12:593223
pubmed: 33584343
Front Immunol. 2019 Jul 31;10:1645
pubmed: 31417542
Stem Cells. 2006 May;24(5):1294-301
pubmed: 16410387
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Clin Transl Med. 2021 Feb;11(2):e297
pubmed: 33634996
Curr Opin Hematol. 2000 Nov;7(6):358-63
pubmed: 11055509
Cell Mol Life Sci. 2017 Jul;74(13):2345-2360
pubmed: 28214990
Biomol Ther (Seoul). 2019 Jan 31;27(1):25-33
pubmed: 29902862
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3621-6
pubmed: 26976597
NPJ Regen Med. 2020 Oct 26;5(1):17
pubmed: 33580031
Signal Transduct Target Ther. 2020 Aug 27;5(1):172
pubmed: 32855385
Cell Immunol. 2011;272(1):33-8
pubmed: 22004796
Signal Transduct Target Ther. 2021 Feb 10;6(1):58
pubmed: 33568628
Stem Cells Transl Med. 2021 May;10(5):660-673
pubmed: 33400390
Stem Cells Dev. 2015 Jan 15;24(2):253-63
pubmed: 25162829
PLoS One. 2021 Mar 23;16(3):e0249090
pubmed: 33755688
EClinicalMedicine. 2020 Jan 17;19:100249
pubmed: 31989101
Annu Rev Pathol. 2011;6:457-78
pubmed: 21073342
PLoS One. 2020 Dec 10;15(12):e0243705
pubmed: 33301514
Cell Biol Toxicol. 2020 Feb;36(1):83-102
pubmed: 31485828
Postgrad Med J. 2020 Jul;96(1137):403-407
pubmed: 32522846
Exp Mol Med. 2013 Nov 15;45:e54
pubmed: 24232253
Transfus Clin Biol. 2021 Aug;28(3):264-270
pubmed: 33901641
J Cell Physiol. 1999 Oct;181(1):67-73
pubmed: 10457354
Arch Med Res. 2021 Jan;52(1):93-101
pubmed: 32977984
Int J Hematol. 2004 Feb;79(2):103-8
pubmed: 15005335
Cell. 2001 May 4;105(3):369-77
pubmed: 11348593
Mol Pharm. 2021 Mar 1;18(3):754-771
pubmed: 33464914
Front Immunol. 2020 Jun 16;11:1446
pubmed: 32612617
Stem Cell Res Ther. 2016 Oct 28;7(1):159
pubmed: 27793190
Infect Drug Resist. 2020 Sep 28;13:3295-3300
pubmed: 33061476
J Microbiol Biotechnol. 2020 Mar 28;30(3):313-324
pubmed: 32238757
Contemp Clin Trials. 2021 Feb;101:106272
pubmed: 33422642
Clin Infect Dis. 2020 Nov 19;71(16):2199-2206
pubmed: 32407459
Croat Med J. 2021 Jun 30;62(3):288-296
pubmed: 34212566
Pharmacol Res. 2020 Jul;157:104833
pubmed: 32302706
Medicine (Baltimore). 2020 Jul 31;99(31):e21429
pubmed: 32756149
J Antimicrob Chemother. 2021 Mar 12;76(4):1078-1084
pubmed: 33374002
Stem Cell Res Ther. 2021 Jan 29;12(1):91
pubmed: 33514427
Haematologica. 2006 Aug;91(8):1017-26
pubmed: 16870554
J Biomed Sci. 2021 Apr 14;28(1):28
pubmed: 33849537
Nat Immunol. 2014 Nov;15(11):1009-16
pubmed: 25329189
Cell Commun Signal. 2011 May 14;9:12
pubmed: 21569606
JAMA. 2020 Oct 6;324(13):1330-1341
pubmed: 32876694
PLoS Med. 2020 Dec 30;17(12):e1003501
pubmed: 33378357
Front Med. 2020 Oct;14(5):664-673
pubmed: 32761491
Stem Cell Res Ther. 2020 Jul 16;11(1):291
pubmed: 32678017
Lancet. 2004 May 1;363(9419):1439-41
pubmed: 15121408
J Intern Med. 2020 Aug;288(2):192-206
pubmed: 32348588
J Med Virol. 2021 Jan;93(1):250-256
pubmed: 32592501
Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):41
pubmed: 31346794
Ann N Y Acad Sci. 2003 May;996:235-44
pubmed: 12799302
Stem Cells. 2005 Apr;23(4):584-93
pubmed: 15790779
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
N Engl J Med. 2021 Feb 18;384(7):666-668
pubmed: 33440086
Med Clin (Engl Ed). 2020 Oct 9;155(7):318-319
pubmed: 32959021
J Infect Dev Ctries. 2020 Oct 31;14(10):1138-1145
pubmed: 33175709
Front Immunol. 2017 Mar 30;8:339
pubmed: 28424688
Stem Cells Dev. 2016 Dec 15;25(24):1843-1852
pubmed: 27702398
Front Bioeng Biotechnol. 2018 Jul 24;6:93
pubmed: 30087891
J Infect. 2020 Jun;80(6):607-613
pubmed: 32283152
Cell Transplant. 2021 Jan-Dec;30:9636897211021008
pubmed: 34074163
Clin Microbiol Infect. 2021 Jan;27(1):83-88
pubmed: 32745596
Postgrad Med J. 2021 May;97(1147):312-320
pubmed: 32978337
Science. 2020 Mar 27;367(6485):1444-1448
pubmed: 32132184
NPJ Regen Med. 2019 Dec 2;4:22
pubmed: 31815001
Cytometry A. 2018 Jul;93(9):894-904
pubmed: 30211967
Curr Stem Cell Res Ther. 2007 Dec;2(4):310-23
pubmed: 18220915
Stem Cells Int. 2015;2015:628767
pubmed: 26273305
Nat Med. 2020 Jul;26(7):1017-1032
pubmed: 32651579
Front Med. 2020 Apr;14(2):185-192
pubmed: 32170560
Pharmacol Res. 2020 Jul;157:104872
pubmed: 32360583
Stem Cell Res Ther. 2020 Aug 18;11(1):361
pubmed: 32811531
Stem Cell Investig. 2020 Sep 08;7:17
pubmed: 33110915
Cytokine Growth Factor Rev. 2020 Jun;53:25-32
pubmed: 32446778
CMAJ. 2020 Jul 6;192(27):E745-E755
pubmed: 32444482
Biomed Pharmacother. 2020 Nov;131:110678
pubmed: 32861070
J Med Virol. 2021 Feb;93(2):1111-1118
pubmed: 32776573
Front Pharmacol. 2020 Oct 29;11:577571
pubmed: 33324210
J Cell Biochem. 2011 Apr;112(4):1206-18
pubmed: 21312238
Crit Care. 2020 Dec 14;24(1):696
pubmed: 33317589
World J Clin Cases. 2021 Mar 6;9(7):1705-1713
pubmed: 33728315
Clin Chim Acta. 2020 Sep;508:254-266
pubmed: 32474009
N Engl J Med. 2020 Nov 5;383(19):1813-1826
pubmed: 32445440
Stem Cell Res Ther. 2020 May 27;11(1):207
pubmed: 32460839
Theranostics. 2021 Jan 1;11(1):316-329
pubmed: 33391477
Int J Oral Sci. 2020 Feb 24;12(1):8
pubmed: 32094336
Clin Immunol. 2021 Jan;222:108634
pubmed: 33217545
Stem Cell Res Ther. 2021 Jul 16;12(1):410
pubmed: 34271988
N Engl J Med. 2021 Feb 18;384(7):610-618
pubmed: 33406353
Transplant Proc. 2009 Apr;41(3):943-6
pubmed: 19376394
J Pathol. 2020 Jul;251(3):228-248
pubmed: 32418199
EClinicalMedicine. 2020 Aug;25:100454
pubmed: 32838232
Cell Prolif. 2020 Dec;53(12):e12947
pubmed: 33205469