Synthetic Antiferromagnetic Gold Nanoparticles as Bimodal Contrast Agents in MRI and CT-An Experimental In Vitro and In Vivo Study.

CT MRI antiferromagnetic nanoparticles bimodal contrast agent computed tomography gold nanoparticles magnetic resonance imaging top down synthesis

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
17 Sep 2021
Historique:
received: 16 08 2021
revised: 14 09 2021
accepted: 15 09 2021
entrez: 28 9 2021
pubmed: 29 9 2021
medline: 29 9 2021
Statut: epublish

Résumé

The use of multimodal contrast agents can potentially overcome the intrinsic limitations of individual imaging methods. We have validated synthetic antiferromagnetic nanoparticles (SAF-NPs) as bimodal contrast agents for in vitro cell labeling and in vivo cell tracking using magnetic resonance imaging (MRI) and computed tomography (CT). SAF-NP-labeled cells showed high contrast in MRI phantom studies (r

Identifiants

pubmed: 34575570
pii: pharmaceutics13091494
doi: 10.3390/pharmaceutics13091494
pmc: PMC8472775
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Agentschap voor Innovatie door Wetenschap en Technologie
ID : IWT 080017 (SBO Imagine)
Organisme : Agentschap voor Innovatie door Wetenschap en Technologie
ID : IWT 140061 (SBO NanoCoMIT)
Organisme : Seventh Framework Programme
ID : FP7-NMP-2008-228933
Organisme : Onderzoeksraad, KU Leuven
ID : C14/20/095
Organisme : Horizon 2020
ID : H2020-NMP-2015-686009 (PANA)
Organisme : Horizon 2020
ID : H2020-FET-OPEN-766456 (AMPHORA)

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Auteurs

Antoine D'Hollander (A)

Biomedical MRI Unit, Department of Imaging and Pathology, KU Leuven, O&N 1, Herestraat 49, 3000 Leuven, Belgium.
Department of Life Science Technology, IMEC, Kapeldreef 75, 3001 Leuven, Belgium.

Ruben Van Roosbroeck (R)

Department of Life Science Technology, IMEC, Kapeldreef 75, 3001 Leuven, Belgium.
Division of Mechatronics, Department of Biosystems, Biostatistics and Sensors, KU Leuven, 3001 Leuven, Belgium.

Jesse Trekker (J)

Biomedical MRI Unit, Department of Imaging and Pathology, KU Leuven, O&N 1, Herestraat 49, 3000 Leuven, Belgium.
Department of Life Science Technology, IMEC, Kapeldreef 75, 3001 Leuven, Belgium.

Tim Stakenborg (T)

Department of Life Science Technology, IMEC, Kapeldreef 75, 3001 Leuven, Belgium.

Tom Dresselaers (T)

Biomedical MRI Unit, Department of Imaging and Pathology, KU Leuven, O&N 1, Herestraat 49, 3000 Leuven, Belgium.

Greetje Vande Velde (G)

Biomedical MRI Unit, Department of Imaging and Pathology, KU Leuven, O&N 1, Herestraat 49, 3000 Leuven, Belgium.

Tom Struys (T)

Lab of Histology, Biomedical Research Institute, Hasselt University, Agora Laan Gebouw C, 3590 Diepenbeek, Belgium.

Ivo Lambrichts (I)

Lab of Histology, Biomedical Research Institute, Hasselt University, Agora Laan Gebouw C, 3590 Diepenbeek, Belgium.

Jeroen Lammertyn (J)

Division of Mechatronics, Department of Biosystems, Biostatistics and Sensors, KU Leuven, 3001 Leuven, Belgium.

Liesbet Lagae (L)

Department of Life Science Technology, IMEC, Kapeldreef 75, 3001 Leuven, Belgium.
Department of Physics, Faculty of Sciences, Laboratory of Soft Matter and Biophysics, KU Leuven, Celestijnenlaan 200D, 3001 Leuven, Belgium.

Uwe Himmelreich (U)

Biomedical MRI Unit, Department of Imaging and Pathology, KU Leuven, O&N 1, Herestraat 49, 3000 Leuven, Belgium.
Department of Life Science Technology, IMEC, Kapeldreef 75, 3001 Leuven, Belgium.

Classifications MeSH