Non-Viral Gene Delivery Systems for Treatment of Myocardial Infarction: Targeting Strategies and Cardiac Cell Modulation.
gene therapy
myocardial infarction
nanoparticles
non-viral delivery systems
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
19 Sep 2021
19 Sep 2021
Historique:
received:
26
07
2021
revised:
06
09
2021
accepted:
14
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality worldwide. Conventional therapies involving surgery or pharmacological strategies have shown limited therapeutic effects due to a lack of cardiac tissue repair. Gene therapy has opened an avenue for the treatment of cardiac diseases through manipulating the underlying gene mechanics. Several gene therapies for cardiac diseases have been assessed in clinical trials, while the clinical translation greatly depends on the delivery technologies. Non-viral vectors are attracting much attention due to their safety and facile production compared to viral vectors. In this review, we discuss the recent progress of non-viral gene therapies for the treatment of cardiovascular diseases, with a particular focus on myocardial infarction (MI). Through a summary of delivery strategies with which to target cardiac tissue and different cardiac cells for MI treatment, this review aims to inspire new insights into the design/exploitation of non-viral delivery systems for gene cargos to promote cardiac repair/regeneration.
Identifiants
pubmed: 34575595
pii: pharmaceutics13091520
doi: 10.3390/pharmaceutics13091520
pmc: PMC8465433
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 31900994
Organisme : Natural Science Foundation of Fujian Province
ID : 2020J01632
Références
Nat Mater. 2006 Jun;5(6):439-51
pubmed: 16738681
J Am Coll Cardiol. 2007 Sep 11;50(11):1038-46
pubmed: 17825712
Adv Mater. 2018 Aug;30(31):e1801570
pubmed: 29920798
Adv Mater. 2019 Nov;31(45):e1805391
pubmed: 30701603
Biomaterials. 2011 Aug;32(22):5213-22
pubmed: 21501867
Cell Mol Life Sci. 2019 Apr;76(7):1365-1380
pubmed: 30578442
Int J Nanomedicine. 2012;7:1671-8
pubmed: 22619519
Cancer Metastasis Rev. 2018 Mar;37(1):107-124
pubmed: 29243000
Nanomedicine. 2020 Jul;27:102201
pubmed: 32278100
ACS Nano. 2014 Jun 24;8(6):5696-706
pubmed: 24821383
Biomaterials. 2009 Feb;30(4):658-64
pubmed: 19007981
Clin Sci (Lond). 2020 Apr 30;134(8):985-999
pubmed: 32297634
Int Immunopharmacol. 2021 Apr;93:107389
pubmed: 33582480
J Control Release. 2017 Sep 10;261:10-22
pubmed: 28625673
J Control Release. 2007 Sep 26;122(2):189-98
pubmed: 17681632
Biomaterials. 2014 Apr;35(11):3697-707
pubmed: 24468403
Nat Nanotechnol. 2013 Oct;8(10):772-81
pubmed: 24056901
J Control Release. 2016 Dec 10;243:182-194
pubmed: 27765623
Theranostics. 2019 Apr 13;9(8):2346-2360
pubmed: 31149048
Biomaterials. 2008 Nov;29(33):4439-46
pubmed: 18725170
J Am Heart Assoc. 2019 Aug 6;8(15):e012089
pubmed: 31315484
Circ Res. 2007 Feb 2;100(2):158-73
pubmed: 17272818
Mol Ther. 2012 Mar;20(3):601-8
pubmed: 22186793
Nat Commun. 2019 Apr 17;10(1):1802
pubmed: 30996254
Sci Robot. 2017 Mar 15;2(4):
pubmed: 31552379
Circ Res. 2015 Jan 16;116(2):237-44
pubmed: 25416133
Circ Res. 2014 Jan 3;114(1):101-8
pubmed: 24065463
Cardiovasc Res. 2019 Jun 1;115(7):1117-1130
pubmed: 30825305
Mol Ther. 2016 Feb;24(1):66-75
pubmed: 26471463
Nat Biotechnol. 2015 Aug;33(8):870-6
pubmed: 26192320
ACS Nano. 2014 Aug 26;8(8):8050-62
pubmed: 24988275
J Mater Chem B. 2020 Dec 7;8(45):10384-10391
pubmed: 33112352
Cell. 2007 Apr 20;129(2):303-17
pubmed: 17397913
Circ Res. 2014 Jul 7;115(2):284-95
pubmed: 24786973
Am J Transl Res. 2017 Jun 15;9(6):3120-3137
pubmed: 28670398
Theranostics. 2020 Jan 1;10(1):218-230
pubmed: 31903116
Stem Cells Int. 2018 Sep 9;2018:3290372
pubmed: 30271437
J Control Release. 2017 Sep 28;262:18-27
pubmed: 28700900
Cell Stem Cell. 2014 Nov 6;15(5):589-604
pubmed: 25517466
Nat Rev Cardiol. 2020 Jun;17(6):327-340
pubmed: 31996800
Nat Commun. 2020 Nov 5;11(1):5618
pubmed: 33154372
IUBMB Life. 2012 Feb;64(2):143-50
pubmed: 22215527
Nat Biomed Eng. 2020 Nov;4(11):1076-1089
pubmed: 33020600
Biomaterials. 2013 Oct;34(31):7790-8
pubmed: 23856052
Compr Physiol. 2013 Apr;3(2):785-97
pubmed: 23720329
Int J Nanomedicine. 2014 Nov 11;9:5203-15
pubmed: 25429216
ACS Biomater Sci Eng. 2015;1(4):201-217
pubmed: 25984572
Gene Ther. 1996 Feb;3(2):145-53
pubmed: 8867862
Contrast Media Mol Imaging. 2013 Mar-Apr;8(2):117-26
pubmed: 23281284
Curr Cardiol Rep. 2019 Sep 16;21(10):131
pubmed: 31529165
Mol Ther. 2009 Jul;17(7):1225-33
pubmed: 19401674
J Control Release. 2012 Sep 10;162(2):276-85
pubmed: 22771978
Circ Res. 2013 Jun 7;112(12):1557-66
pubmed: 23575307
Nat Rev Drug Discov. 2005 Jul;4(7):581-93
pubmed: 16052241
Gene Ther. 2004 Oct;11 Suppl 1:S10-7
pubmed: 15454952
Circ Res. 2012 May 25;110(11):1465-73
pubmed: 22539765
J Am Coll Cardiol. 2014 Apr 22;63(15):1556-66
pubmed: 24361318
J Control Release. 2015 Apr 10;203:23-38
pubmed: 25665866
J Mol Cell Cardiol. 2016 Apr;93:149-55
pubmed: 26593722
Adv Mater. 2016 Sep;28(33):7204-12
pubmed: 27297033
J Control Release. 2013 Jun 10;168(2):125-34
pubmed: 23500061
Biomacromolecules. 2019 Aug 12;20(8):3076-3086
pubmed: 31305991
Front Immunol. 2015 Jan 29;6:19
pubmed: 25688245
Cardiovasc Res. 2020 May 1;116(6):1101-1112
pubmed: 31841135
Gene Ther. 2009 Jan;16(1):52-9
pubmed: 18701915
Biomaterials. 2020 Oct;257:120256
pubmed: 32736263
J Control Release. 2016 Sep 10;237:1-13
pubmed: 27369865
Nat Nanotechnol. 2021 Jun;16(6):630-643
pubmed: 34059811
Adv Healthc Mater. 2020 Jun;9(11):e1901783
pubmed: 32338452
Circ Res. 2017 Sep 1;121(6):677-694
pubmed: 28860318
ACS Nano. 2013 Sep 24;7(9):7442-7
pubmed: 24490875
Circulation. 2003 Jun 10;107(22):2857-63
pubmed: 12771000
Circulation. 2013 May 21;127(20):2038-46
pubmed: 23616627
Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H981-3
pubmed: 15706047
Mol Med. 2006 Sep-Oct;12(9-10):214-20
pubmed: 17225869
Pharmaceutics. 2020 Jun 21;12(6):
pubmed: 32575874
Biosci Rep. 1981 May;1(5):377-85
pubmed: 6271283
J Am Chem Soc. 2004 Jun 23;126(24):7422-3
pubmed: 15198572
Lancet. 2016 Mar 19;387(10024):1178-86
pubmed: 26803443
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1827-32
pubmed: 21245355
Sci Rep. 2016 May 10;6:25613
pubmed: 27161857
Cardiovasc Res. 2019 Jul 1;115(8):1266-1285
pubmed: 30918936
Science. 2009 Apr 3;324(5923):98-102
pubmed: 19342590
Circ J. 2016 Oct 25;80(11):2269-2276
pubmed: 27746422
J Control Release. 2015 Feb 28;200:167-78
pubmed: 25575863
J Control Release. 2012 Oct 10;163(1):10-7
pubmed: 22776291
Mol Ther. 2013 Jul;21(7):1390-402
pubmed: 23774796
Int J Nanomedicine. 2017 Apr 12;12:3023-3036
pubmed: 28442910
Biomaterials. 2011 Nov;32(32):8304-18
pubmed: 21840594
Nat Metab. 2020 Feb;2(2):167-178
pubmed: 32617517
Annu Rev Pharmacol Toxicol. 2016;56:103-22
pubmed: 26738473
Nanomedicine. 2018 Feb;14(2):619-631
pubmed: 29269324
Nat Biomed Eng. 2020 Jul;4(7):717-731
pubmed: 32632229
Acc Chem Res. 2019 May 21;52(5):1255-1264
pubmed: 30977635
J Biomed Nanotechnol. 2018 May 1;14(5):968-977
pubmed: 29883566
Nat Rev Genet. 2007 Aug;8(8):573-87
pubmed: 17607305
Mol Pharm. 2012 May 7;9(5):1302-9
pubmed: 22452378
J Control Release. 2013 Oct 10;171(1):24-32
pubmed: 23806842
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1972-7
pubmed: 12571356
Gene Ther. 2006 Nov;13(21):1503-11
pubmed: 16791287
Sci Transl Med. 2016 Jun 8;8(342):342ra80
pubmed: 27280687
Nat Rev Genet. 2014 Aug;15(8):541-55
pubmed: 25022906
J Card Fail. 2009 Apr;15(3):171-81
pubmed: 19327618
Adv Mater. 2019 Dec;31(49):e1903637
pubmed: 31566258
Nat Mater. 2016 Nov;15(11):1212-1221
pubmed: 27525571
Circulation. 2010 Sep 14;122(11 Suppl):S124-31
pubmed: 20837903
NPJ Regen Med. 2021 Feb 15;6(1):8
pubmed: 33589632
J Mol Cell Cardiol. 2012 Dec;53(6):801-8
pubmed: 22884737
Eur Heart J. 2015 Sep 1;36(33):2207-9
pubmed: 26071429
J Mol Cell Cardiol. 2011 May;50(5):841-8
pubmed: 21316369
Biomed Pharmacother. 2017 May;89:297-304
pubmed: 28236703
Int J Nanomedicine. 2010 Apr 07;5:231-7
pubmed: 20463939
Cell Cycle. 2020 Feb;19(3):339-353
pubmed: 31924121
Circ Res. 2019 Jun 21;125(1):14-25
pubmed: 30964391
Nat Rev Immunol. 2015 Feb;15(2):117-29
pubmed: 25614321
Eur Heart J. 2006 Jan;27(2):237-45
pubmed: 16166101
Hum Gene Ther Methods. 2013 Oct;24(5):298-306
pubmed: 23944648
Eur Heart J. 2015 Sep 1;36(33):2228-38
pubmed: 26056125
Bull Exp Biol Med. 2011 Nov;152(1):105-7
pubmed: 22803053
Circulation. 2020 Apr 14;141(15):1249-1265
pubmed: 32078387
Nature. 2013 May 9;497(7448):249-253
pubmed: 23594737
Biomaterials. 2010 Nov;31(31):8081-7
pubmed: 20674007
Circ Res. 1978 Sep;43(3):337-47
pubmed: 354819
Nat Rev Drug Discov. 2019 Jun;18(6):421-446
pubmed: 30846871
Nano Lett. 2011 Oct 12;11(10):4411-4
pubmed: 21899318
Nature. 2013 Mar 7;495(7439):107-10
pubmed: 23426265
Chem Rev. 2009 Feb;109(2):259-302
pubmed: 19053809
J Control Release. 2018 Sep 10;285:152-161
pubmed: 29981357
PLoS One. 2012;7(7):e39490
pubmed: 22844395
Circ Res. 2007 Feb 2;100(2):174-90
pubmed: 17272819
J Clin Invest. 2004 Mar;113(6):885-94
pubmed: 15067321
Circulation. 2019 Jun 4;139(23):2668-2684
pubmed: 30832495
Circ Res. 2017 Apr 14;120(8):1298-1304
pubmed: 28077443
Drug Deliv. 2020 Dec;27(1):1-14
pubmed: 31818156
Circ Res. 2011 Sep 2;109(6):670-9
pubmed: 21778430
Theranostics. 2013;3(3):201-9
pubmed: 23471415
J Mol Cell Cardiol. 2020 May;142:65-79
pubmed: 32087217
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11498-502
pubmed: 8265580
J Cardiovasc Transl Res. 2011 Oct;4(5):631-43
pubmed: 21833815
Mol Pharm. 2013 Jan 7;10(1):378-85
pubmed: 23214982
J Am Coll Cardiol. 2009 Feb 24;53(8):709-17
pubmed: 19232905
Expert Opin Biol Ther. 2013 Dec;13(12):1749-53
pubmed: 23957658
Nat Rev Drug Discov. 2020 Oct;19(10):673-694
pubmed: 32782413
JAMA Cardiol. 2016 May 1;1(2):163-71
pubmed: 27437887
Circulation. 2011 Jul 19;124(3):304-13
pubmed: 21709064
Biomaterials. 2018 Apr;162:47-59
pubmed: 29432988
Nature. 2018 Aug;560(7718):291-292
pubmed: 30108348
Nature. 2012 Dec 20;492(7429):376-81
pubmed: 23222520
J Ultrasound Med. 2011 Sep;30(9):1247-58
pubmed: 21876096
Nat Biomed Eng. 2017;1:983-992
pubmed: 29354322
J Mol Biol. 2004 Sep 3;342(1):171-82
pubmed: 15313615
N Engl J Med. 2018 Jul 5;379(1):11-21
pubmed: 29972753
Adv Healthc Mater. 2016 Oct;5(20):2686-2697
pubmed: 27592617
ACS Nano. 2013 Mar 26;7(3):2212-20
pubmed: 23432114
J Card Fail. 2008 Jun;14(5):355-67
pubmed: 18514926
Hum Gene Ther. 2006 Mar;17(3):253-63
pubmed: 16544975
J Am Coll Cardiol. 2003 Oct 15;42(8):1339-47
pubmed: 14563572
Lancet. 2016 Oct 8;388(10053):1725-1774
pubmed: 27733285
Nat Mater. 2020 May;19(5):566-575
pubmed: 31932672
Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3008-3010
pubmed: 29450950
Bioconjug Chem. 2006 Jan-Feb;17(1):101-8
pubmed: 16417257
Cell Mol Life Sci. 2017 Mar;74(6):983-1000
pubmed: 27714411
Biomater Sci. 2016 Aug 16;4(9):1291-309
pubmed: 27480033
J Control Release. 2013 Sep 10;170(2):287-94
pubmed: 23665256
Nat Commun. 2019 Aug 8;10(1):3561
pubmed: 31395892
Sci Rep. 2014 Mar 07;4:4257
pubmed: 24604065
Gene Ther. 2013 Feb;20(2):225-33
pubmed: 23151517
Biotechnol Bioeng. 2007 Mar 1;96(4):795-802
pubmed: 17051598
Nat Biotechnol. 2011 Oct 09;29(11):1005-10
pubmed: 21983520
Biomaterials. 2013 May;34(14):3729-36
pubmed: 23433774
Acta Biomater. 2020 Mar 1;104:176-187
pubmed: 31945505
Nat Biotechnol. 2013 Oct;31(10):898-907
pubmed: 24013197
Biores Open Access. 2020 Dec 02;9(1):258-268
pubmed: 33376632
Adv Mater. 2020 Dec;32(48):e2003598
pubmed: 33103807
Eur Heart J. 2011 Aug;32(16):2075-84
pubmed: 21196445
Int J Nanomedicine. 2021 Jun 01;16:3741-3754
pubmed: 34113099
Nat Nanotechnol. 2017 May;12(4):387-393
pubmed: 27992410
Theranostics. 2017 Jan 1;7(1):51-66
pubmed: 28042316
Nano Lett. 2018 Sep 12;18(9):5885-5891
pubmed: 30141949
Biochim Biophys Acta. 1996 Feb 21;1279(1):75-83
pubmed: 8624365
Theranostics. 2017 May 2;7(7):1953-1965
pubmed: 28638481
Drug Discov Today. 2021 Jul;26(7):1602-1619
pubmed: 33781953
Mol Immunol. 2021 Aug;136:26-35
pubmed: 34058620
J Inflamm (Lond). 2015 Feb 10;12:11
pubmed: 25685072
J Mol Med (Berl). 2017 Dec;95(12):1369-1385
pubmed: 28948298
Sci Adv. 2018 Jun 27;4(6):eaar8409
pubmed: 29963629
Circ Res. 2016 Feb 5;118(3):400-9
pubmed: 26635390
Science. 2016 Jun 3;352(6290):1216-20
pubmed: 27127239
J Mol Cell Cardiol. 2014 May;70:47-55
pubmed: 24625635
Science. 1977 Nov 18;198(4318):735-8
pubmed: 910155
Am Heart J. 2010 Mar;159(3):354-60
pubmed: 20211295
Adv Mater. 2021 Jun 13;:e2100241
pubmed: 34121236
Drug Deliv. 2017 Nov;24(1):83-91
pubmed: 28155538
Curr Drug Targets. 2015;16(14):1671-81
pubmed: 26601723
J Control Release. 2021 Mar 10;331:62-73
pubmed: 33460670
J Control Release. 2015 Dec 28;220(Pt A):556-567
pubmed: 26122651
ACS Nano. 2019 Sep 24;13(9):9880-9894
pubmed: 31149806