Selinexor and the Selective Inhibition of Nuclear Export: A New Perspective on the Treatment of Sarcomas and Other Solid and Non-Solid Tumors.
SINE
XPO1
gynecologic cancer
leukemia
metastatic cancer
multiple myeloma
selinexor
soft tissue sarcoma
target therapy
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
20 Sep 2021
20 Sep 2021
Historique:
received:
06
07
2021
revised:
15
09
2021
accepted:
16
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Nucleocytoplasmic transport has been found dysregulated in many types of cancer and is often described as a poor prognostic factor. Specifically, Exportin-1 (XPO1) has been found overexpressed in many tumors and has become an attractive target in molecular oncology and therapeutics development. The selective inhibitor of nuclear export, Selinexor, is one of the most scientifically interesting drugs that targets XPO1 in clinical development. In this review, we summarized the most relevant preclinical and clinical results achieved for non-solid tumors, sarcomas, and other kind of solid tumors.
Identifiants
pubmed: 34575598
pii: pharmaceutics13091522
doi: 10.3390/pharmaceutics13091522
pmc: PMC8466603
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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