Endometrial SUSD2

MSC biomaterials bioscaffolds cell culture electrospinning endometrium menstrual blood nanofiber perivascular MSC tissue engineering

Journal

Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269

Informations de publication

Date de publication:
26 Aug 2021
Historique:
received: 11 07 2021
revised: 19 08 2021
accepted: 21 08 2021
entrez: 28 9 2021
pubmed: 29 9 2021
medline: 29 9 2021
Statut: epublish

Résumé

Cellular therapy is an emerging field in clinical and personalised medicine. Many adult mesenchymal stem/progenitor cells (MSC) or pluripotent derivatives are being assessed simultaneously in preclinical trials for their potential treatment applications in chronic and degenerative human diseases. Endometrial mesenchymal stem/progenitor cells (eMSC) have been identified as clonogenic cells that exist in unique perivascular niches within the uterine endometrium. Compared with MSC isolated from other tissue sources, such as bone marrow and adipose tissue, eMSC can be extracted through less invasive methods of tissue sampling, and they exhibit improvements in potency, proliferative capacity, and control of culture-induced differentiation. In this review, we summarize the potential cell therapy and tissue engineering applications of eMSC in pelvic organ prolapse (POP), emphasising their ability to exert angiogenic and strong immunomodulatory responses that improve tissue integration of novel surgical constructs for POP and promote vaginal tissue healing.

Identifiants

pubmed: 34575617
pii: jpm11090840
doi: 10.3390/jpm11090840
pmc: PMC8471527
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

David M Z B Hennes (DMZB)

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3168, Australia.
Pelvic Floor Disorders Unit, Monash Health, Clayton, VIC 3168, Australia.

Anna Rosamilia (A)

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3168, Australia.
Pelvic Floor Disorders Unit, Monash Health, Clayton, VIC 3168, Australia.

Jerome A Werkmeister (JA)

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3168, Australia.

Caroline E Gargett (CE)

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3168, Australia.

Shayanti Mukherjee (S)

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3168, Australia.

Classifications MeSH