Neurochemical Features of Rem Sleep Behaviour Disorder.
REM sleep behavior disorder
acetyl-choline
dopaminergic dysfunction
neurochemistry
neurotransmitters
noradrenalin
synucleopathies
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
31 Aug 2021
31 Aug 2021
Historique:
received:
08
08
2021
revised:
30
08
2021
accepted:
30
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Dopaminergic deficiency, shown by many studies using functional neuroimaging with Single Photon Emission Computerized Tomography (SPECT) and Positron Emission Tomography (PET), is the most consistent neurochemical feature of rapid eye movement (REM) sleep behaviour disorder (RBD) and, together with transcranial ultrasonography, and determination of alpha-synuclein in certain tissues, should be considered as a reliable marker for the phenoconversion of idiopathic RBD (iRBD) to a synucleopathy (Parkinson's disease -PD- or Lewy body dementia -LBD). The possible role in the pathogenesis of RBD of other neurotransmitters such as noradrenaline, acetylcholine, and excitatory and inhibitory neurotransmitters; hormones such as melatonin, and proinflammatory factors have also been suggested by recent reports. In general, brain perfusion and brain glucose metabolism studies have shown patterns resembling partially those of PD and LBD. Finally, the results of structural and functional MRI suggest the presence of structural changes in deep gray matter nuclei, cortical gray matter atrophy, and alterations in the functional connectivity within the basal ganglia, the cortico-striatal, and the cortico-cortical networks, but they should be considered as preliminary.
Identifiants
pubmed: 34575657
pii: jpm11090880
doi: 10.3390/jpm11090880
pmc: PMC8468296
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spain
ID : PI15/00303
Organisme : Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spain
ID : PI18/00540
Organisme : Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spain
ID : RETICS RD16/0006/0004
Organisme : Junta de Extremadura, Spain
ID : GR18145 .
Organisme : Junta de Extremadura, Spain
ID : IB16170
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