Interrogating Epigenome toward Personalized Approach in Cutaneous Melanoma.
biomarkers
cutaneous melanoma
drug resistance
epigenetic regulation
epigenetic therapy
immune response
inflammation
therapeutic targets
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
09 Sep 2021
09 Sep 2021
Historique:
received:
11
08
2021
revised:
06
09
2021
accepted:
06
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Epigenetic alterations have emerged as essential contributors in the pathogenesis of various human diseases, including cutaneous melanoma (CM). Unlike genetic changes, epigenetic modifications are highly dynamic and reversible and thus easy to regulate. Here, we present a comprehensive review of the latest research findings on the role of genetic and epigenetic alterations in CM initiation and development. We believe that a better understanding of how aberrant DNA methylation and histone modifications, along with other molecular processes, affect the genesis and clinical behavior of CM can provide the clinical management of this disease a wide range of diagnostic and prognostic biomarkers, as well as potential therapeutic targets that can be used to prevent or abrogate drug resistance. We will also approach the modalities by which these epigenetic alterations can be used to customize the therapeutic algorithms in CM, the current status of epi-therapies, and the preliminary results of epigenetic and traditional combinatorial pharmacological approaches in this fatal disease.
Identifiants
pubmed: 34575678
pii: jpm11090901
doi: 10.3390/jpm11090901
pmc: PMC8467841
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : International Nucleome Consortium (INC)
ID : PN III P1 1.2 PCCDI 2017 0341/2018
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