Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism.
cancer stem cells
hypoxia
hypoxia-inducible factors
induced pluripotent stem cells
metabolism
oxygen
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
10 Sep 2021
10 Sep 2021
Historique:
received:
16
07
2021
revised:
30
08
2021
accepted:
08
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Human-induced pluripotent stem cells (hiPSCs) offer numerous possibilities in science and medicine, particularly when combined with precise genome editing methods. hiPSCs are artificially generated equivalents of human embryonic stem cells (hESCs), which possess an unlimited ability to self-renew and the potential to differentiate into any cell type of the human body. Importantly, generating patient-specific hiPSCs enables personalized drug testing or autologous cell therapy upon differentiation into a desired cell line. However, to ensure the highest standard of hiPSC-based biomedical products, their safety and reliability need to be proved. One of the key factors influencing human pluripotent stem cell (hPSC) characteristics and function is oxygen concentration in their microenvironment. In recent years, emerging data have pointed toward the beneficial effect of low oxygen pressure (hypoxia) on both hiPSCs and hESCs. In this review, we examine the state-of-the-art research on the oxygen impact on hiPSC functions and activity with an emphasis on their niche, metabolic state, reprogramming efficiency, and differentiation potential. We also discuss the similarities and differences between PSCs and cancer stem cells (CSCs) with respect to the role of oxygen in both cell types.
Identifiants
pubmed: 34575682
pii: jpm11090905
doi: 10.3390/jpm11090905
pmc: PMC8466012
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Narodowe Centrum Nauki
ID : UMO-2016/23/D/NZ3/01310
Organisme : Uniwersytet Jagielloński w Krakowie
ID : U1C/P04/NO/02.02
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